Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,822 questions · 1,891 findings · 321 reviews · Headline outcomes only

No studies found 279 · 14.8%GRADE not reported 46 · 2.4%Very low 524 · 27.7%Low 571 · 30.2%Moderate 330 · 17.5%High 141 · 7.5%

IM injection vs IA injection

Wound/ulcer healing: number of participants with healing ulcer · people with critical limb ischaemia

IM injection showed no clear difference in wound/ulcer healing: number of participants with healing ulcer compared with IA injection (low certainty).

1 finding from 1 review

Low molecular weight heparin vs placebo or no prophylaxis

Deep vein thrombosis · prevention of venous thromboembolism in patients with lower‐limb immobilization

Low molecular weight heparin probably leads to lower deep venous thrombosis compared with no prophylaxis or placebo (moderate certainty).

1 finding from 1 review

Low molecular weight heparin vs placebo or no prophylaxis

Pulmonary embolism · prevention of venous thromboembolism in patients with lower‐limb immobilization

Low molecular weight heparin showed no clear difference in pulmonary embolism compared with no prophylaxis or placebo (low certainty).

1 finding from 1 review

Low molecular weight heparin vs placebo or no prophylaxis

Symptomatic venous thromboembolism · prevention of venous thromboembolism in patients with lower‐limb immobilization

Low molecular weight heparin may leads to lower symptomatic venous thromboembolism compared with no prophylaxis or placebo (low certainty).

1 finding from 1 review

Low molecular weight heparin vs placebo or no prophylaxis

Mortality due to other causes · prevention of venous thromboembolism in patients with lower‐limb immobilization

Low molecular weight heparin showed no clear difference in mortality due to other causes compared with no prophylaxis or placebo (low certainty).

1 finding from 1 review

Low molecular weight heparin vs placebo or no prophylaxis

Adverse outcomes · prevention of venous thromboembolism in patients with lower‐limb immobilization

Low molecular weight heparin showed no clear difference in adverse outcomes compared with no prophylaxis or placebo (low certainty).

1 finding from 1 review

Summary of findings table for the comparison of 'intensified patient care' vs usual care

Adherence to antipsychotic medication: number of missed doses, average endpoint data, short term (up to 6 months) · People receiving lipid‐lowering medications

Summary of findings table for the comparison of 'intensified patient… probably leads to higher medication adherence at ≤ 6 months compared with 'usual care' (moderate certainty).

1 finding from 1 review

Summary of findings table for the comparison of 'intensified patient care' vs usual care

Medication adherence (dichotomous) · People receiving lipid‐lowering medications

Summary of findings table for the comparison of 'intensified patient… leads to higher medication adherence at > 6 months compared with 'usual care' (high certainty).

1 finding from 1 review

Intervention not reported

Incidence of any surgical site infection · lower limb arterial surgery

It is very uncertain whether the intervention changes incidence of any surgical site infection (very low certainty).

1 finding from 1 review