Azithromycin vs doxycycline
Lesion count · Participants with rosacea
1 finding from 1 review
- no estimate extracted1 study · 67 participantsVery low
Findings
What do systematic reviews say?
1,133 questions · 1,153 findings · 36 reviews · Skin
No studies found 407 · 35.3%GRADE not reported 90 · 7.8%Very low 183 · 15.9%Low 209 · 18.1%Moderate 211 · 18.3%High 53 · 4.6%
Azithromycin vs doxycycline
Time needed until improvement of the skin lesions · Participants with rosacea
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Azithromycin vs doxycycline
Duration of remission · Participants with rosacea
1 finding from 1 review
- no estimate extracted1 study · 67 participantsVery low
Doxycycline 40 mg + metronidazole 1% gel vs doxycycline 100 mg + metronidazole 1% gel
HRQOL ‐ not measured · Participants with rosacea
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Azelaic acid vs placebo
HRQOL ‐ not measured · Participants with rosacea
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Doxycycline 40 mg + metronidazole 1% gel vs doxycycline 100 mg + metronidazole 1% gel
Participant‐assessed improvement in rosacea severity ‐ not measured · Participants with rosacea
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Doxycycline 40 mg + metronidazole 1% gel vs doxycycline 100 mg + metronidazole 1% gel
Proportion of participants with adverse event · Participants with rosacea
Doxycycline 40 mg + metronidazole 1% gel may leads to lower proportion of participants with adverse event compared with doxycycline 100 mg + metronidazole 1% gel (low certainty).
1 finding from 1 review
- RR 0.25 [0.11, 0.54]1 study · 91 participantsLow
Doxycycline 40 mg + metronidazole 1% gel vs doxycycline 100 mg + metronidazole 1% gel
Physician‐assessed improvement in rosacea severity · Participants with rosacea
1 finding from 1 review
- no estimate extracted1 study · 91 participantsLow
Doxycycline 40 mg + metronidazole 1% gel vs doxycycline 100 mg + metronidazole 1% gel
Assessment of erythema or telangiectasia · Participants with rosacea
1 finding from 1 review
- no estimate extracted1 study · 91 participantsLow
Doxycycline 40 mg + metronidazole 1% gel vs doxycycline 100 mg + metronidazole 1% gel
Lesion count · Participants with rosacea
1 finding from 1 review
- no estimate extracted1 study · 91 participantsLow
Doxycycline 40 mg + metronidazole 1% gel vs doxycycline 100 mg + metronidazole 1% gel
Time needed until improvement of the skin lesions · Participants with rosacea
1 finding from 1 review
- no estimate extracted1 study · 91 participantsLow
Doxycycline 40 mg + metronidazole 1% gel vs doxycycline 100 mg + metronidazole 1% gel
Duration of remission ‐ not measured · Participants with rosacea
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Doxycycline 40 mg + azelaic acid gel vs doxycycline 40 mg + metronidazole gel
HRQOL ‐ not measured · Participants with rosacea
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Doxycycline 40 mg + azelaic acid gel vs doxycycline 40 mg + metronidazole gel
Participant‐assessed improvement in rosacea severity · Participants with rosacea
Doxycycline 40 mg + azelaic acid gel showed no clear difference in participant‐assessed improvement in rosacea severity Excellent… compared with doxycycline 40 mg + metronidazole gel (high certainty).
1 finding from 1 review
- RR 1.05 [0.79, 1.4]1 study · 207 participantsHigh
Doxycycline 40 mg + azelaic acid gel vs doxycycline 40 mg + metronidazole gel
Proportion of participants with adverse event · Participants with rosacea
Doxycycline 40 mg + azelaic acid gel showed no clear difference in proportion of participants with adverse event compared with doxycycline 40 mg + metronidazole gel (high certainty).
1 finding from 1 review
- RR 0.27 [0.06, 1.28]1 study · 207 participantsHigh
Adalimumab weekly vs placebo
Change in DLQI score (LOCF) · participants with hidradenitis suppurativa
2 findings from 1 review
- no estimate extracted1 study · 102 participantsModerate
- no estimate extracted1 study · 102 participantsModerate
Adalimumab every other week vs placebo
Treatment discontinuation · participants with hidradenitis suppurativa
Adalimumab every other week showed no clear difference in frequency of treatment discontinuation compared with placebo (high certainty).
1 finding from 1 review
- RR 4.91 [0.24, 99.74]2 studies · 124 participantsHigh
Adalimumab every other week vs placebo
Proportion of participants with infectious adverse effects · participants with hidradenitis suppurativa
Adalimumab every other week showed no clear difference in proportion of participants with infectious adverse effects compared with placebo (high certainty).
1 finding from 1 review
- RR 1.6 [0.57, 4.53]2 studies · 124 participantsHigh
Adalimumab every other week vs placebo
Change in Pain VAS · participants with hidradenitis suppurativa
1 finding from 1 review
- no estimate extracted1 study · 21 participantsLow
Adalimumab every other week vs placebo
Proportion with improvement in pain · participants with hidradenitis suppurativa
Adalimumab every other week showed no clear difference in proportion with improvement in pain compared with placebo (moderate certainty).
1 finding from 1 review
- RR 1.34 [0.73, 2.43]1 study · 95 participantsModerate