Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,192 questions · 1,243 findings · 151 reviews

No studies found 252 · 20.3%GRADE not reported 180 · 14.5%Very low 291 · 23.4%Low 282 · 22.7%Moderate 174 · 14%High 64 · 5.1%

Sodium hypochlorite (NaOCl), 2.5% to 5.25% vs Sodium hypochlorite 1%

Proportion of participants with moderate to severe pain up to 6 hours after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…

The review found no eligible studies for this question.

1 finding from 1 review

Sodium hypochlorite 1.3% with MTAD final rinse vs Sodium hypochlorite 1.3% with normal saline final rinse

Change in periapical radiolucency (radiography or CBCT), up to 1 year after treatment · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…

The review found no eligible studies for this question.

1 finding from 1 review

Sodium hypochlorite 5.25% vs Sodium hypochlorite 5.25% with hydrogen peroxide 3%

Proportion of participants with moderate to severe pain 72 hours to 14 days after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…

Sodium hypochlorite 5.25% showed no clear difference in proportion of participants with moderate to severe pain 72 hours to… compared with sodium hypochlorite 5.25% with hydrogen peroxide 3%; GRADE not reported.

1 finding from 1 review

Immediate-delayed implants (placed within 8 weeks after tooth extraction) vs Delayed implants (placed at least 2 months after extraction)

Major complications at the implant site · Patients with compromised teeth to be extracted who require single dental implants in fresh postextraction sockets

Immediate-delayed implants (placed within 8 weeks after tooth… led to higher major complications at the implant site compared with delayed implants (placed at least 2 months after extraction); GRADE not reported.

1 finding from 1 review

Bio-Oss (anorganic bovine bone) vs Bovine-derived xenograft (Bio-Oss) plus resorbable barrier

Bone gain (horizontal - HDD) · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)

Bio-Oss (anorganic bovine bone) showed no clear difference in bone gain (horizontal - HDD) compared with bio-Oss + resorbable barrier; GRADE not reported.

1 finding from 1 review

Non-resorbable barrier (guided bone regeneration) vs Resorbable barrier + particulate autogenous bone

Vertical bone gain · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)

Non-resorbable barrier (guided bone regeneration) showed no clear difference in bone gain (vertical - VDH) compared with resorbable barrier + autogenous bone; GRADE not reported.

1 finding from 1 review

Non-resorbable barrier (guided bone regeneration) vs Resorbable barrier + particulate autogenous bone

Bone gain (horizontal - HDD) · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)

Non-resorbable barrier (guided bone regeneration) showed no clear difference in bone gain (horizontal - HDD) compared with resorbable barrier + autogenous bone; GRADE not reported.

1 finding from 1 review

Immediate implants (placed in a fresh extraction socket just after tooth extraction) vs Delayed implants (placed at least 2 months after extraction)

Marginal bone level change · Patients with compromised teeth to be extracted who require single dental implants in fresh postextraction sockets

Immediate implants (placed in a fresh extraction socket just after… showed no clear difference in perimplant marginal bone level changes compared with delayed implants (placed at least 2 months after extraction, in…; GRADE not reported.

1 finding from 1 review

Autogenous bone graft augmentation at the immediate implant site vs No augmentation

Prosthesis failure · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)

Autogenous bone graft augmentation at the immediate implant site led to lower prosthesis failure compared with no augmentation; GRADE not reported.

1 finding from 1 review

Resorbable barrier (guided bone regeneration) vs Non-resorbable barrier (guided bone regeneration)

Bone gain (horizontal - HDD) · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)

Resorbable barrier (guided bone regeneration) showed no clear difference in bone gain (horizontal - HDD) compared with non-resorbable barrier (guided bone regeneration); GRADE not reported.

1 finding from 1 review

Bio-Oss (anorganic bovine bone) vs Bovine-derived xenograft (Bio-Oss) plus resorbable barrier

Vertical bone gain · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)

Bio-Oss (anorganic bovine bone) showed no clear difference in bone gain (vertical - VDH) compared with bio-Oss + resorbable barrier; GRADE not reported.

1 finding from 1 review

Non-resorbable barrier (guided bone regeneration) vs Resorbable barrier + particulate autogenous bone

Major complications at the implant/donor site · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)

Non-resorbable barrier (guided bone regeneration) led to lower major complications at the implant/donor site compared with resorbable barrier + autogenous bone; GRADE not reported.

1 finding from 1 review

Immediate implants (placed in a fresh extraction socket just after tooth extraction) vs Delayed implants (placed at least 2 months after extraction)

Prosthesis failure · Patients with compromised teeth to be extracted who require single dental implants in fresh postextraction sockets

Immediate implants (placed in a fresh extraction socket just after… showed no clear difference in prosthesis failure compared with delayed implants (placed at least 2 months after extraction, in…; GRADE not reported.

1 finding from 1 review

Resorbable barrier (guided bone regeneration) vs Non-resorbable barrier (guided bone regeneration)

Vertical bone gain · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)

Resorbable barrier (guided bone regeneration) showed no clear difference in bone gain (vertical - VDH) compared with non-resorbable barrier (guided bone regeneration); GRADE not reported.

1 finding from 1 review

Resorbable barrier (guided bone regeneration) vs Resorbable barrier + particulate autogenous bone

Vertical bone gain · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)

Resorbable barrier (guided bone regeneration) showed no clear difference in bone gain (vertical - VDH) compared with resorbable barrier + autogenous bone; GRADE not reported.

1 finding from 1 review

Resorbable barrier (guided bone regeneration) vs Resorbable barrier + particulate autogenous bone

Bone gain (horizontal - HDD) · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)

Resorbable barrier (guided bone regeneration) showed no clear difference in bone gain (horizontal - HDD) compared with resorbable barrier + autogenous bone; GRADE not reported.

1 finding from 1 review

Resorbable barrier (guided bone regeneration) vs Resorbable barrier + particulate autogenous bone

Major complications at the implant/donor site · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)

Resorbable barrier (guided bone regeneration) led to lower major complications at the implant/donor site compared with resorbable barrier + autogenous bone; GRADE not reported.

1 finding from 1 review

Immediate-delayed implants (placed within 8 weeks after tooth extraction) vs Delayed implants (placed at least 2 months after extraction)

Aesthetics assessed by dentist: interproximal papilla dimension · Patients with compromised teeth to be extracted who require single dental implants in fresh postextraction sockets

Immediate-delayed implants (placed within 8 weeks after tooth… led to lower aesthetics assessed by dentist: interproximal papilla dimension compared with delayed implants (placed at least 2 months after extraction); GRADE not reported.

1 finding from 1 review

Immediate-delayed implants (placed within 8 weeks after tooth extraction) vs Delayed implants (placed at least 2 months after extraction)

Implant failure · Patients with compromised teeth to be extracted who require single dental implants in fresh postextraction sockets

Immediate-delayed implants (placed within 8 weeks after tooth… led to lower implant failure compared with delayed implants (placed at least 2 months after extraction); GRADE not reported.

1 finding from 1 review

Bio-Oss (anorganic bovine bone) vs Bovine-derived xenograft (Bio-Oss) plus resorbable barrier

Major complication at augmented site · Patients receiving immediate single implants in fresh extraction sockets (maxillary anterior/premolar sites)

Bio-Oss (anorganic bovine bone) led to lower major complications at the augmented site compared with bio-Oss + resorbable barrier; GRADE not reported.

1 finding from 1 review