Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,710 questions · 14,842 findings · 1,394 reviews

No studies found 2,880 · 19.4%GRADE not reported 1,413 · 9.5%Very low 3,103 · 20.9%Low 3,870 · 26.1%Moderate 2,663 · 17.9%High 913 · 6.2%

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Inhaled tobramycin (TNS) vs placebo

Isolation of other micro‐organisms from the respiratory tract: number of positive cultures per patient year · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen

The review found no eligible studies for this question.

1 finding from 1 review

Inhaled tobramycin (TNS) vs placebo

Adverse effects of antibiotics: participants experiencing cough · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen

It is very uncertain whether inhaled tobramycin (TNS) changes adverse effects of antibiotics: participants experiencing cough compared with placebo (very low certainty).

1 finding from 1 review

Pentoxifylline with antibiotics (any dose or duration) vs placebo or no intervention

All‐cause mortality during hospital stay · neonates with sepsis

Pentoxifylline with antibiotics (any dose or duration) may leads to lower all‐cause mortality during hospital stay compared with placebo or no intervention (low certainty).

1 finding from 1 review

Pentoxifylline with antibiotics (any dose or duration) vs placebo or no intervention

Severe intraventricular haemorrhage · neonates with sepsis

It is very uncertain whether pentoxifylline with antibiotics (any dose or duration) changes severe intraventricular haemorrhage compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Pentoxifylline with antibiotics (any dose or duration) vs placebo or no intervention

Periventricular leukomalacia · neonates with sepsis

It is very uncertain whether pentoxifylline with antibiotics (any dose or duration) changes periventricular leukomalacia compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Pentoxifylline with antibiotics (any dose or duration) vs placebo or no intervention

Length of hospital stay · neonates with sepsis

Pentoxifylline with antibiotics (any dose or duration) showed no clear difference in length of hospital stay (LOS) in days compared with placebo or no intervention (low certainty).

1 finding from 1 review

Pentoxifylline with antibiotics (any dose or duration) vs placebo or no intervention

Necrotising enterocolitis · neonates with sepsis

It is very uncertain whether pentoxifylline with antibiotics (any dose or duration) changes necrotising enterocolitis, any Bell stage compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Pentoxifylline with antibiotics (any dose or duration) vs placebo or no intervention

Retinopathy of prematurity · neonates with sepsis

It is very uncertain whether pentoxifylline with antibiotics (any dose or duration) changes retinopathy of prematurity, any stage compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Prednisone vs placebo or supportive treatment

Any continuing kidney disease at 3 months (study with high risk of bias excluded) · patients with IgAV

Prednisone showed no clear difference in children with any continuing kidney disease at 3 months compared with placebo or supportive treatment (moderate certainty).

2 findings from 1 review

Prednisone vs placebo or supportive treatment

Any continuing kidney disease at 12 months (study with high risk of bias excluded) · patients with IgAV

Prednisone showed no clear difference in children with any continuing kidney disease at 12 months compared with placebo or supportive treatment (low certainty).

2 findings from 1 review

Systemic aminocaproic acid vs placebo

Short‐term visual acuity 20/40 or better ≤ 2 weeks after treatment · people with traumatic hyphema

Systemic aminocaproic acid showed no clear difference in short‐term visual acuity 20/40 or better ≤ 2 weeks after treatment compared with placebo (low certainty).

1 finding from 1 review

Topical aminocaproic acid vs placebo

Secondary hemorrhage at any time point · people with traumatic hyphema

Topical aminocaproic acid showed no clear difference in secondary hemorrhage at any time point compared with placebo (low certainty).

1 finding from 1 review