Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)
1000 to 1250 ppm F toothpaste leads to lower caries increment, surface index D(M)FS compared with non-fluoride (0 ppm F) placebo toothpaste (high certainty).
1 finding from 1 review
SMD -0.28 [-0.32, -0.25]
55 studies
High
Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)
2400 to 2800 ppm F toothpaste showed no clear difference in caries increment, surface index D(M)FS compared with 1450 to 1500 ppm F toothpaste (moderate certainty).
1 finding from 1 review
SMD -0.05 [-0.14, 0.05]
2 studies
Moderate
Proportion developing new caries · Young children with primary (deciduous) dentition (aged 1 to 6 years at study start)
1450 ppm F toothpaste showed no clear difference in proportion developing new caries compared with 250 ppm F toothpaste (low certainty).
1 finding from 1 review
Microbial reduction (viable count, log CFU/mL) · Patients with dental caries (in vivo cariogenic microorganisms, including children with early childhood caries)
In randomized clinical trials, photodynamic therapy significantly reduced cariogenic microbial counts versus untreated control (SMD -1.16, 95% CI -2.02 to -0.30; 2 trials), but heterogeneity was high (I2=70%) and considered too high to rely on; certainty was not graded.
1 finding from 1 review
Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)
250 ppm F toothpaste showed no clear difference in caries increment, tooth index D(M)FT compared with non-fluoride (0 ppm F) placebo toothpaste (low certainty).
1 finding from 1 review
SMD -0.11 [-0.27, 0.05]
1 study
Low
Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)
440 to 550 ppm F toothpaste showed no clear difference in caries increment, surface index D(M)FS compared with 250 ppm F toothpaste (low certainty).
1 finding from 1 review
SMD 0.03 [-0.17, 0.23]
1 study
Low
Proportion developing new caries · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)
250 ppm F toothpaste showed no clear difference in proportion developing new caries compared with non-fluoride (0 ppm F) placebo toothpaste (low certainty).
1 finding from 1 review
Discomfort associated with the procedure · People with dental caries in primary teeth (mainly children)
ART using high-viscosity glass ionomer cement (H-GIC), hand… showed no clear difference in participant experience (discomfort during procedure) compared with conventional treatment using H-GIC (rotary instruments); GRADE not reported.
1 finding from 1 review
Adverse effects (apart from fluorosis) · Pregnant women (for preventing dental caries in the primary teeth of their children)
1 finding from 1 review
no estimate extracted
1 study
GRADE not reported
Restoration failure (primary dentition) · Children with carious primary teeth
ART using H-GIC showed no clear difference in restoration failure (primary teeth) compared with conventional treatment using amalgam; GRADE not reported.
1 finding from 1 review
OR 2.15 [0.73, 6.35]
2 studies
GRADE not reported
Restoration failure (primary dentition) · Children with carious primary teeth
ART using H-GIC led to higher restoration failure (primary teeth) compared with conventional treatment using composite (with local anaesthetic); GRADE not reported.
1 finding from 1 review
Pain (during procedure, primary dentition) · People with dental caries in primary teeth (mainly children)
ART using high-viscosity glass ionomer cement (H-GIC), hand… showed no clear difference in pain (during procedure, primary dentition) compared with conventional treatment using H-GIC (rotary instruments) (low certainty).
1 finding from 1 review
Filled primary surfaces at 3 years · Pregnant women (for preventing dental caries in the primary teeth of their children)
Fluoride supplementation (tablets, drops, lozenges or chewing gum) showed no clear difference in filled primary surfaces at 5 years compared with placebo or no treatment; GRADE not reported.
2 findings from 1 review
Costs (direct and indirect) · People with dental caries in primary teeth (mainly children)
The review found no eligible studies for this question.
1 finding from 1 review
Fluorosis (maxillary teeth) at 5 years · Pregnant women (for preventing dental caries in the primary teeth of their children)
It is very uncertain whether fluoride supplementation (tablets, drops, lozenges or chewing gum) changes fluorosis (maxillary teeth) at 5 years compared with placebo or no treatment (very low certainty).
1 finding from 1 review
Pain (primary dentition) · Children with carious primary teeth
ART using H-GIC showed no clear difference in pain (primary dentition) compared with conventional treatment using composite (with local anaesthetic); GRADE not reported.
1 finding from 1 review
OR 2.22 [0.51, 9.61]
1 study
GRADE not reported
Caries in primary teeth: dmft (3 years) · Pregnant women (for preventing dental caries in the primary teeth of their children)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Restoration failure (primary dentition) · Children and adolescents with dental caries (primary teeth and permanent immature teeth)
ART using glass ionomer cement (GIC) showed no clear difference in restoration failure (primary teeth) compared with conventional treatment using amalgam; GRADE not reported.
1 finding from 1 review
Adverse events · People with dental caries in primary teeth (mainly children)
The review found no eligible studies for this question.
1 finding from 1 review
Missing primary surfaces (ms) · Pregnant women (for preventing dental caries in the primary teeth of their children)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found