Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,835 questions · 1,886 findings · 74 reviews · Skin

No studies found 542 · 28.7%GRADE not reported 130 · 6.9%Very low 326 · 17.3%Low 434 · 23%Moderate 348 · 18.5%High 106 · 5.6%

Barrier creams vs no treatment

The proportion of participants developing any signs and symptoms of OIHD (incident cases) measured by clinical scores (IGA) or hand dermatitis scores (e.g. HECSI, Manuscore), or both, as rated by the investigator (physician/nurse) or the participa... · workers at risk of occupational irritant hand dermatitis

Barrier creams showed no clear difference in the proportion of participants developing any signs and symptoms of… compared with no treatment (low certainty).

1 finding from 1 review

Moisturisers vs no treatment

The proportion of participants developing any signs and symptoms of OIHD (incident cases) measured by clinical scores (IGA) or hand dermatitis scores (e.g. HECSI, Manuscore), or both, as rated by the investigator (physician/nurse) or the participa... · workers at risk of occupational irritant hand dermatitis

Moisturisers showed no clear difference in the proportion of participants developing any signs and symptoms of… compared with no treatment (low certainty).

1 finding from 1 review

Barrier creams and moisturisers vs no treatment

The proportion of participants developing any signs and symptoms of OIHD (incident cases) measured by clinical scores (IGA) or hand dermatitis scores (e.g. HECSI, Manuscore), or both, as rated by the investigator (physician/nurse) or the participa... · workers at risk of occupational irritant hand dermatitis

Barrier creams and moisturisers showed no clear difference in the proportion of participants developing any signs and symptoms of… compared with no treatment (low certainty).

1 finding from 1 review

Skin protection education vs no intervention or minimal intervention

The proportion of participants developing any signs and symptoms of OIHD (incident cases) measured by clinical scores (IGA) or hand dermatitis scores (e.g. HECSI, Manuscore), or both, as rated by the investigator (physician/nurse) or the participa... · workers at risk of occupational irritant hand dermatitis

It is very uncertain whether skin protection education changes the proportion of participants developing any signs and symptoms of… compared with no or minimal intervention (very low certainty).

1 finding from 1 review

Intervention not reported

Primary outcome 1: participant‐ or parent‐rated symptoms of eczema (SCORAD part C) at the end of active treatment Visual analogue scale for itch and sleep disturbance ranging from 0 to 10 for each symptom and combined ranging from 0 to 20. The hig... · male and female patients 0 to 55 years of age with physician‐diagnosed eczema
1 finding from 1 review

Intervention not reported

Primary outcome 1: participant‐ or parent‐rated global change in eczema symptoms at the end of active treatment (binary outcome) Change in risk for worsened/unchanged eczema Duration of · male and female patients 0 to 55 years of age with physician‐diagnosed eczema

The intervention showed no clear difference in primary outcome 1: participant‐ or parent‐rated global change in… (low certainty).

1 finding from 1 review

Intervention not reported

Primary outcome 2: participant‐ or parent‐rated participant quality of life score at the end of active treatment Scales used: DLQI, IDQoL, Skindex‐29, CDLQI. On those scales, the higher the score, the more severely the quality of life is affected ... · male and female patients 0 to 55 years of age with physician‐diagnosed eczema
1 finding from 1 review

Intervention not reported

Primary outcome 2: participant‐ or parent‐rated family quality of life score at the end of active treatment Scale used: DFI, FDLQI. On those scales, the higher the score, the more severely the quality of life is affected Duration of · male and female patients 0 to 55 years of age with physician‐diagnosed eczema
1 finding from 1 review

Intervention not reported

Secondary outcome 4: global eczema severity score (total SCORAD) at the end of active treatment (Investigator‐rated eczema severity) Scale used: total SCORAD ranging from 0 to 103. The higher the score, the more severe the disease Duration of · male and female patients 0 to 55 years of age with physician‐diagnosed eczema
1 finding from 1 review