Intervention not reported
- Addition of long‐acting beta2 agonists or long‐acting muscarinic antagonists versus doubling the dose of inhaled… 2023 · Cochrane Headline outcomes onlyno estimate extracted4 studies · 1685 participantsModerate
Summary of findings table ‐ Repeat dose(s) of prenatal corticosteroid showed no clear difference in A1: Fetal or neonatal or infant death (< 1 year of age) – all… compared with single course (moderate certainty).
Summary of findings table ‐ Repeat dose(s) of prenatal corticosteroid leads to lower A5: Respiratory distress syndrome – all fetuses randomised compared with single course (high certainty).
Summary of findings table ‐ Repeat dose(s) of prenatal corticosteroid probably leads to lower A7: Severe lung disease – all fetuses randomised compared with single course (moderate certainty).
Summary of findings table ‐ Repeat dose(s) of prenatal corticosteroid showed no clear difference in A8: Chronic lung disease – all fetuses randomised compared with single course (high certainty).
Summary of findings table ‐ Repeat dose(s) of prenatal corticosteroid showed no clear difference in A9: Severe intraventricular haemorrhage (grade 3 or 4) – all fetuses… compared with single course (moderate certainty).
Summary of findings table ‐ Repeat dose(s) of prenatal corticosteroid showed no clear difference in A11: Necrotising enterocolitis – all fetuses randomised compared with single course (moderate certainty).
Summary of findings table ‐ Repeat dose(s) of prenatal corticosteroid probably leads to lower A12: Composite of serious outcomes– all fetuses randomised compared with single course (moderate certainty).
The review found no eligible studies for this question.
Dexamethasone showed no clear difference in neurodevelopmental disability at compared with betamethasone – child outcomes (moderate certainty).
Dexamethasone showed no clear difference in visual impairment compared with betamethasone – child outcomes (low certainty).
Dexamethasone showed no clear difference in hearing impairment compared with betamethasone – child outcomes (moderate certainty).
Dexamethasone showed no clear difference in developmental delay –motor (mild, moderate or severe) compared with betamethasone – child outcomes (moderate certainty).
Dexamethasone showed no clear difference in intellectual impairment: developmental delay – cognitive or language… compared with betamethasone – child outcomes (moderate certainty).
Dexamethasone showed no clear difference in cerebral palsy compared with betamethasone – child outcomes (low certainty).
It is very uncertain whether dexamethasone: oral changes any known death after randomisation (fetal, neonatal, child, child… compared with intramuscular – fetal/neonatal outcomes (very low certainty).
It is very uncertain whether dexamethasone: oral changes respiratory distress syndrome compared with intramuscular – fetal/neonatal outcomes (very low certainty).
It is very uncertain whether dexamethasone: oral changes intraventricular haemorrhage compared with intramuscular – fetal/neonatal outcomes (very low certainty).
It is very uncertain whether dexamethasone: oral changes necrotising enterocolitis compared with intramuscular – fetal/neonatal outcomes (very low certainty).
Dexamethasone showed no clear difference in chorioamnionitis compared with betamethasone – maternal outcomes (moderate certainty).