Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,695 questions · 4,979 findings · 433 reviews

No studies found 998 · 20%GRADE not reported 1,140 · 22.9%Very low 1,024 · 20.6%Low 1,029 · 20.7%Moderate 636 · 12.8%High 152 · 3.1%

Direct oral anticoagulant (DOAC) prophylaxis vs no prophylaxis

All‐cause mortality · ambulatory people with cancer without venous thromboembolism receiving systemic therapy

Direct oral anticoagulant (DOAC) prophylaxis showed no clear difference in mortality compared with no prophylaxis (moderate certainty).

1 finding from 1 review

Direct oral anticoagulant (DOAC) prophylaxis vs no prophylaxis

Pulmonary embolism · ambulatory people with cancer without venous thromboembolism receiving systemic therapy

Direct oral anticoagulant (DOAC) prophylaxis probably leads to lower pulmonary embolism compared with no prophylaxis (moderate certainty).

1 finding from 1 review

Direct oral anticoagulant (DOAC) prophylaxis vs no prophylaxis

Symptomatic DVT · ambulatory people with cancer without venous thromboembolism receiving systemic therapy

Direct oral anticoagulant (DOAC) prophylaxis showed no clear difference in symptomatic deep vein thrombosis compared with no prophylaxis (moderate certainty).

1 finding from 1 review

Direct oral anticoagulant (DOAC) prophylaxis vs no prophylaxis

Major bleeding · ambulatory people with cancer without venous thromboembolism receiving systemic therapy

Direct oral anticoagulant (DOAC) prophylaxis showed no clear difference in major bleeding compared with no prophylaxis (moderate certainty).

1 finding from 1 review

Direct oral anticoagulant (DOAC) prophylaxis vs no prophylaxis

Minor bleeding · ambulatory people with cancer without venous thromboembolism receiving systemic therapy

Direct oral anticoagulant (DOAC) prophylaxis showed no clear difference in minor bleeding compared with no prophylaxis (low certainty).

1 finding from 1 review

Oral anti‐diabetic pharmacological therapies vs placebo (outcomes

Hypertensive disorders of pregnancy · women diagnosed with gestational diabetes; 24‐30 weeks' gestation; singleton pregnancy.

It is very uncertain whether oral anti‐diabetic pharmacological therapies changes hypertensive disorders of pregnancy ‐ (any type) compared with placebo ‐ maternal outcomes (very low certainty).

1 finding from 1 review

Oral anti‐diabetic pharmacological therapies vs placebo (outcomes

Neonatal hypoglycaemia · Infants of women diagnosed with gestational diabetes

It is very uncertain whether oral anti‐diabetic pharmacological therapies changes neonatal hypoglycaemia compared with placebo ‐ neonatal outcomes (very low certainty).

1 finding from 1 review

Oral anti‐diabetic pharmacological therapies vs placebo (outcomes

Caearean section · women diagnosed with gestational diabetes; 24‐30 weeks' gestation; singleton pregnancy.

It is very uncertain whether oral anti‐diabetic pharmacological therapies changes caearean section compared with placebo ‐ maternal outcomes (very low certainty).

1 finding from 1 review

Oral anti‐diabetic pharmacological therapies vs placebo (outcomes

Perineal trauma · women diagnosed with gestational diabetes; 24‐30 weeks' gestation; singleton pregnancy.

It is very uncertain whether oral anti‐diabetic pharmacological therapies changes perineal trauma compared with placebo ‐ maternal outcomes (very low certainty).

1 finding from 1 review

Oral anti‐diabetic pharmacological therapies vs placebo (outcomes

Induction of labour · women diagnosed with gestational diabetes; 24‐30 weeks' gestation; singleton pregnancy.

It is very uncertain whether oral anti‐diabetic pharmacological therapies changes induction of labour compared with placebo ‐ maternal outcomes (very low certainty).

1 finding from 1 review

Oral anti‐diabetic pharmacological therapies vs placebo (outcomes

Large‐for‐gestational age · Infants of women diagnosed with gestational diabetes

It is very uncertain whether oral anti‐diabetic pharmacological therapies changes large‐for‐gestational age compared with placebo ‐ neonatal outcomes (very low certainty).

1 finding from 1 review