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Evidence found and GRADE certainty

1,268 questions · 1,343 findings · 197 reviews

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No studies found 317 · 23.6%GRADE not reported 189 · 14.1%Very low 356 · 26.5%Low 271 · 20.2%Moderate 173 · 12.9%High 37 · 2.8%

Summary of findings table ‐ Recombinant activated factor VII vs placebo/open control

All serious adverse events · adults with acute spontaneous intracerebral haemorrhage

It is very uncertain whether summary of findings table ‐ Recombinant activated factor VII changes all serious adverse events compared with placebo/open control (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Recombinant activated factor VII vs placebo/open control

Death from any cause · adults with acute spontaneous intracerebral haemorrhage

Summary of findings table ‐ Recombinant activated factor VII showed no clear difference in death from any cause compared with placebo/open control (moderate certainty).

1 finding from 1 review

Antifibrinolytic therapy (tranexamic acid or epsilon aminocaproic acid) vs placebo/open control

Death or dependence (mRS 4 to 6) at day 90 · adults with acute spontaneous intracerebral haemorrhage

Summary of findings table ‐ Antifibrinolytic drug(s) showed no clear difference in death or dependence (mRS 4–6) compared with placebo/open control (high certainty).

1 finding from 1 review

Antifibrinolytic therapy (tranexamic acid or epsilon aminocaproic acid) vs placebo/open control

Intracerebral haemorrhage expansion by 24 hours · adults with acute spontaneous intracerebral haemorrhage

Summary of findings table ‐ Antifibrinolytic drug(s) leads to lower intracerebral haemorrhage expansion by 24 hours compared with placebo/open control (high certainty).

1 finding from 1 review

Medical vs open surgical PD catheter insertion

Catheter tip migration (mechanical failure) · improving catheter function and clinical outcomes in PD patients

It is very uncertain whether medical changes catheter tip migration (mechanical failure) compared with open surgical PD catheter insertion (very low certainty).

1 finding from 1 review

Percutaneous vs open surgical PD catheter insertion

Early PD catheter function (within 4 weeks of PD catheter insertion) · improving catheter function and clinical outcomes in PD patients

It is very uncertain whether percutaneous changes early PD catheter function (within 4 weeks of PD catheter insertion) compared with open surgical PD catheter insertion (very low certainty).

1 finding from 1 review