Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,100 questions · 1,164 findings · 107 reviews

No studies found 280 · 24.1%GRADE not reported 159 · 13.7%Very low 292 · 25.1%Low 274 · 23.5%Moderate 113 · 9.7%High 46 · 4%

Antioxidants vs placebo

Global impression of deterioration (investigator defined global impression of deterioration) · people with multiple sclerosis

Antioxidant showed no clear difference in global impression of deterioration (investigator defined global… compared with placebo (low certainty).

1 finding from 1 review

Antioxidants vs placebo

Number of participants with gadolinium‐enhancing T1 lesions on MRI · people with multiple sclerosis

It is very uncertain whether antioxidant changes MRI activity(assessed as number of participants with… compared with placebo (very low certainty).

1 finding from 1 review

PUFA vs monounsaturated fatty acid (MUFA)

Global impression of deterioration (investigator defined global impression of deterioration) · people with multiple sclerosis

Polyunsaturated fatty acid (PUFA) showed no clear difference in global impression of deterioration (investigator defined global… compared with monounsaturated fatty acid (MUFA) (low certainty).

1 finding from 1 review

Omega‐3 vs omega‐6

Global impression of deterioration (investigator defined global impression of deterioration) · people with multiple sclerosis

Omega‐3 showed no clear difference in global impression of deterioration (investigator defined global… compared with omega‐6 (moderate certainty).

1 finding from 1 review