Findings

What do systematic reviews say?

1,296 questions · 1,330 findings · 157 reviews · Headline outcomes only

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No studies found 297 · 22.3%GRADE not reported 88 · 6.6%Very low 327 · 24.6%Low 317 · 23.8%Moderate 239 · 18%High 62 · 4.7%

Topical quinolone vs intramuscular gentamicin

Hearing · adults with CSOM

1 finding from 1 review

Topical versus systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
Very low

Topical quinolone vs intramuscular gentamicin

Serious complications · adults with CSOM

1 finding from 1 review

Topical versus systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
Very low

Topical quinolone vs intramuscular gentamicin

Suspected ototoxicity · adults with CSOM

1 finding from 1 review

Topical versus systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
Very low

Topical quinolone vs oral amoxicillin‐clavulanic acid combination

Resolution of ear discharge ‐ measured at 1 to 2 weeks · adults with CSOM

It is very uncertain whether topical quinolone changes resolution of ear discharge ‐ 1 to 2 weeks compared with oral amoxicillin‐clavulanic acid combination (very low certainty).

1 finding from 1 review

Topical versus systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes only
RR 2.93 [1.5, 5.72]
1 study · 56 participants
Very low

Topical quinolone vs oral amoxicillin‐clavulanic acid combination

Resolution of ear discharge ‐ measured after 4 weeks · adults with CSOM

The review found no eligible studies for this question.

1 finding from 1 review

Topical versus systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical quinolone vs oral amoxicillin‐clavulanic acid combination

Health‐related quality of life · adults with CSOM

The review found no eligible studies for this question.

1 finding from 1 review

Topical versus systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical quinolone vs oral amoxicillin‐clavulanic acid combination

Ear pain (otalgia) or discomfort or local irritation · adults with CSOM

1 finding from 1 review

Topical versus systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 56 participants
Very low

Topical quinolone vs oral amoxicillin‐clavulanic acid combination

Hearing · adults with CSOM

1 finding from 1 review

Topical versus systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 56 participants
Very low

Topical quinolone vs quinolones

Resolution of ear discharge ‐ measured after 4 weeks · people (of any age) with CSOM

The review found no eligible studies for this question.

1 finding from 1 review

Topical versus systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical quinolone vs oral amoxicillin‐clavulanic acid combination

Serious complications · adults with CSOM

The review found no eligible studies for this question.

1 finding from 1 review

Topical versus systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical quinolone vs oral amoxicillin‐clavulanic acid combination

Suspected ototoxicity · adults with CSOM

1 finding from 1 review

Topical versus systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 56 participants
Very low

Topical quinolone vs quinolones

Health‐related quality of life · people (of any age) with CSOM

The review found no eligible studies for this question.

1 finding from 1 review

Topical versus systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical quinolone vs quinolones

Ear pain (otalgia) or discomfort or local irritation · people (of any age) with CSOM

The review found no eligible studies for this question.

1 finding from 1 review

Topical versus systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical quinolone vs quinolones

Hearing · people (of any age) with CSOM

The review found no eligible studies for this question.

1 finding from 1 review

Topical versus systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical quinolone vs quinolones

Serious complications · people (of any age) with CSOM

The review found no eligible studies for this question.

1 finding from 1 review

Topical versus systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical quinolone vs quinolones

Suspected ototoxicity · people (of any age) with CSOM

1 finding from 1 review

Topical versus systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 265 participants
Very low

Topical quinolone vs intramuscular gentamicin

Resolution of ear discharge ‐ measured at 1 to 2 weeks · adults with CSOM

The review found no eligible studies for this question.

1 finding from 1 review

Topical versus systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical quinolone vs intramuscular gentamicin

Resolution of ear discharge ‐ measured after 4 weeks · adults with CSOM

The review found no eligible studies for this question.

1 finding from 1 review

Topical versus systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Cefepime vs ceftazidime

All‐cause mortality maximum · neonates and children with hospital‐acquired pneumonia

It is very uncertain whether cefepime changes all‐cause mortality Maximum compared with ceftazidime (very low certainty).

1 finding from 1 review

Antibiotics for hospital‐acquired pneumonia in neonates and children 2021 · Cochrane Headline outcomes only
RR 0.14 [0.01, 2.55]
1 study · 30 participants
Very low

Linezolid vs vancomycin

Health‐related quality of life Maximum · neonates and children with hospital‐acquired pneumonia

The review found no eligible studies for this question.

1 finding from 1 review

Antibiotics for hospital‐acquired pneumonia in neonates and children 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found