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Evidence found and GRADE certainty

2,543 questions · 2,589 findings · 168 reviews · Schizophrenia

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No studies found 601 · 23.2%GRADE not reported 446 · 17.2%Very low 721 · 27.8%Low 505 · 19.5%Moderate 274 · 10.6%High 42 · 1.6%

Zuclopenthixol dihydrochloride vs chlorpromazine

Adverse effects: Clinically important general adverse effect (EPSEs) · schizophrenia

It is very uncertain whether zuclopenthixol dihydrochloride changes adverse effects: Clinically important general adverse effect (EPSEs) compared with chlorpromazine (very low certainty).

1 finding from 1 review

CLOZAPINE + AMISULPIRIDE vs CLOZAPINE + QUETIAPINE (Genc 2007)

Leaving the study early · people with treatment‐resistant schizophrenia

It is very uncertain whether CLOZAPINE + AMISULPIRIDE changes leaving the study early: acceptability of treatment ‐ as measured by… compared with CLOZAPINE + QUETIAPINE (Genc 2007) (very low certainty).

1 finding from 1 review

CLOZAPINE + RISPERIDONE vs CLOZAPINE + SULPIRIDE (Kong 2001)

Clinical response: no clinically significant response in mental state: 20% to 50% reduction in PANSS total score · people with treatment‐resistant schizophrenia

It is very uncertain whether CLOZAPINE + RISPERIDONE changes clinical response: no clinically significant response in mental… compared with CLOZAPINE + SULPIRIDE (Kong 2001) (very low certainty).

1 finding from 1 review

CLOZAPINE + RISPERIDONE vs CLOZAPINE + SULPIRIDE (Kong 2001)

Quality of life/satisfaction with care for either recipients of care or carers: significant change in quality of life/satisfaction · people with treatment‐resistant schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review