Findings

What do systematic reviews say?

2,261 questions · 2,280 findings · 114 reviews · Cystic Fibrosis and Genetic Disorders

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No studies found 856 · 37.5%GRADE not reported 58 · 2.5%Very low 550 · 24.1%Low 502 · 22%Moderate 271 · 11.9%High 43 · 1.9%

Hydroxyurea vs no hydroxyurea

Measures of ANC · people with sickle cell disease

1 finding from 1 review

Hydroxyurea (hydroxycarbamide) for sickle cell disease 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 44 participants
Very low

Hydroxyurea vs no hydroxyurea

Quality of life · people with sickle cell disease

The review found no eligible studies for this question.

1 finding from 1 review

Hydroxyurea (hydroxycarbamide) for sickle cell disease 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hydroxyurea vs no hydroxyurea

Adverse events or toxicity · people with sickle cell disease

1 finding from 1 review

Hydroxyurea (hydroxycarbamide) for sickle cell disease 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 44 participants
Very low

Hydroxyurea vs placebo

Measures of HbF · people with sickle cell disease

1 finding from 1 review

Hydroxyurea (hydroxycarbamide) for sickle cell disease 2022 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 784 participants
Low

Hydroxyurea vs placebo

Measures of ANC · people with sickle cell disease

1 finding from 1 review

Hydroxyurea (hydroxycarbamide) for sickle cell disease 2022 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 724 participants
Moderate

Hydroxyurea vs placebo

Health status and quality of life · people with sickle cell disease

1 finding from 1 review

Hydroxyurea (hydroxycarbamide) for sickle cell disease 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 277 participants
Low

Hydroxyurea vs placebo

Adverse events or toxicity: differences in rates of specific adverse events · people with sickle cell disease

1 finding from 1 review

Hydroxyurea (hydroxycarbamide) for sickle cell disease 2022 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 784 participants
Low

Summary of findings ‐ Hydroxyurea and phlebotomy vs transfusion and chelation

Pain alteration: proportion experiencing serious VOC or sickle‐related pain events · adults and children with sickle cell disease and an increased risk of stroke

Summary of findings ‐ Hydroxyurea and phlebotomy may leads to higher pain alteration: proportion experiencing serious VOC or… compared with transfusion and chelation (low certainty).

1 finding from 1 review

Hydroxyurea (hydroxycarbamide) for sickle cell disease 2022 · Cochrane Headline outcomes only
RR 3.37 [1.59, 7.11]
2 studies · 254 participants
Low

Summary of findings ‐ Hydroxyurea and phlebotomy vs transfusion and chelation

Life‐threatening illness · adults and children with sickle cell disease and an increased risk of stroke

1 finding from 1 review

Hydroxyurea (hydroxycarbamide) for sickle cell disease 2022 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 254 participants
Moderate

Physical activity vs no physical activity

Change in VO2 peak during maximal exercise · adults and children with cystic fibrosis

1 finding from 1 review

Physical activity and exercise training in cystic fibrosis 2022 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 348 participants
Moderate

Physical activity vs no physical activity

FEV1 % predicted: absolute change from baseline · adults and children with cystic fibrosis

1 finding from 1 review

Physical activity and exercise training in cystic fibrosis 2022 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 367 participants
Low

Physical activity vs no physical activity

HRQoL score (physical functioning) (change from baseline) · adults and children with cystic fibrosis

1 finding from 1 review

Physical activity and exercise training in cystic fibrosis 2022 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 247 participants
Low

Physical activity vs no physical activity

QoL (CFQ‐R) Respiratory domain · adults and children with cystic fibrosis

1 finding from 1 review

Physical activity and exercise training in cystic fibrosis 2022 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 251 participants
Low

Physical activity vs no physical activity

Pulmonary exacerbations · adults and children with cystic fibrosis

1 finding from 1 review

Physical activity and exercise training in cystic fibrosis 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 117 participants
High

Physical activity vs no physical activity

Diabetic control · adults and children with cystic fibrosis

1 finding from 1 review

Physical activity and exercise training in cystic fibrosis 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 91 participants
Moderate

Physical activity vs no physical activity

Adverse events: number of adverse events Active intervention: 12 months · adults and children with cystic fibrosis

1 finding from 1 review

Physical activity and exercise training in cystic fibrosis 2022 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 156 participants
Low

Appetite stimulants vs placebo

Change in weight (kg) · adults and children with cystic fibrosis

2 findings from 1 review

Appetite stimulants for people with cystic fibrosis 2022 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 42 participants
Low
Appetite stimulants for people with cystic fibrosis 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 17 participants
Low

Appetite stimulants vs placebo

Change in weight z score · adults and children with cystic fibrosis

2 findings from 1 review

Appetite stimulants for people with cystic fibrosis 2022 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 40 participants
Low
Appetite stimulants for people with cystic fibrosis 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 17 participants
Low

Appetite stimulants vs placebo

FEV1 % predicted: absolute change from baseline · adults and children with cystic fibrosis

2 findings from 1 review

Appetite stimulants for people with cystic fibrosis 2022 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 42 participants
Low
Appetite stimulants for people with cystic fibrosis 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 17 participants
Low

Appetite stimulants vs placebo

Increase in appetite (subjective reporting) · adults and children with cystic fibrosis

Appetite stimulants may leads to higher increase in appetite (subjective reporting) compared with placebo (low certainty).

1 finding from 1 review

Appetite stimulants for people with cystic fibrosis 2022 · Cochrane Headline outcomes only
OR 45.25 [3.57, 573.33]
2 studies · 23 participants
Low