Mortality (all cause) · Adults (general population)
Meta-analysis of randomised trials of vitamin D supplementation for Mortality (all cause) (Vitamin D2, general population): RR 1.04 (95% CI 0.97 to 1.11), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
2 findings from 1 review
Number of painful days · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care
Sucralfate suspension (topical) showed no clear difference in number of painful days compared with placebo suspension; GRADE not reported.
1 finding from 1 review
Performance measures: balance sway · Older or community-dwelling adults
Meta-analysis of randomised trials of vitamin D supplementation for Performance measures: balance sway, Older adults: SMD -0.20 (95% CI -0.39 to -0.01), statistically significant. Umbrella review outcome-level evidence grade: Suggestive.
1 finding from 1 review
SMD -0.20 [-0.39, -0.01]
3 studies
GRADE not reported
Performance measures: lower extremity strength · Older or community-dwelling adults
Meta-analysis of randomised trials of vitamin D supplementation for Performance measures: lower extremity strength, Older adults: SMD 0.05 (95% CI -0.11 to 0.20), not statistically significant. Umbrella review outcome-level evidence grade: Substantial effect unlikely.
1 finding from 1 review
SMD 0.05 [-0.11, 0.20]
3 studies
GRADE not reported
Postoperative pain or distress · Children and young people aged 17 years or younger having dental treatment (including extractions) under general anaesthesia (secondary…
1 finding from 1 review
Because of substantial clinical and methodological heterogeneity in the studies, we were unable to determine an estimate of effect
6 studies · 542 participants
Very low
Improvement in oral ulcer score · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care
Colchicine (systemic; 0.5 mg three times daily for 6 months) showed no clear difference in improvement in oral ulcer score compared with placebo; GRADE not reported.
1 finding from 1 review
Vascular calcification · Adults with chronic kidney disease requiring dialysis
Meta-analysis of randomised trials of vitamin D supplementation for Vascular calcification: RR 1.09 (95% CI 0.45 to 2.67), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
All‐cause mortality · Adults with chronic kidney disease requiring dialysis
Meta-analysis of randomised trials of vitamin D supplementation for Mortality: RR 1.34 (95% CI 0.34 to 5.24), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
Serum fasting triglyceride (TG, mmol/L) · Adults (general population)
Meta-analysis of randomised trials of vitamin D supplementation for Triglycerides: WMD -1.92 (95% CI -7.72 to 3.88), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
WMD -1.92 [-7.72, 3.88]
8 studies
GRADE not reported
Pain associated with oral ulcers · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care
1 finding from 1 review
SoF (topical interventions vs placebo), grouped comment spanning all four listed outcomes (verbatim): "5 placebo-controlled trials evaluated topical interventions (sucralfate suspension (2 trials), interferon-alpha (2…
Studies not reported
GRADE not reported
High density lipoprotein · Adults (general population)
Meta-analysis of randomised trials of vitamin D supplementation for High density lipoprotein: WMD -0.14 (95% CI -0.99 to 0.71), not statistically significant. Umbrella review outcome-level evidence grade: Substantial effect unlikely.
1 finding from 1 review
WMD -0.14 [-0.99, 0.71]
8 studies
GRADE not reported
Falls · Older or community-dwelling adults
Meta-analysis of randomised trials of vitamin D supplementation for Falls, Older adults: OR 0.97 (95% CI 0.84 to 1.11), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
3 findings from 1 review
OR 0.97 [0.84, 1.11]
10 studies
GRADE not reported
RAR 0.55 [0.19, 1.64]
2 studies
GRADE not reported
RAR 1.14 [1.03, 1.27]
2 studies
GRADE not reported
Head circumference (mm) · pregnant women
Meta-analysis of randomised trials of vitamin D supplementation for Head circumference at birth: WMD 0.43 (95% CI 0.06 to 0.79), statistically significant. Umbrella review outcome-level evidence grade: Suggestive.
1 finding from 1 review
WMD 0.43 [0.06, 0.79]
2 studies
GRADE not reported
Low birthweight · pregnant women
Meta-analysis of randomised trials of vitamin D supplementation for Low birth weight: RR 0.4 (95% CI 0.23 to 0.71), statistically significant. Umbrella review outcome-level evidence grade: Probable.
1 finding from 1 review
Parental satisfaction · Children and young people aged 17 years or younger having dental treatment (including extractions) under general anaesthesia (secondary…
The review found no eligible studies for this question.
1 finding from 1 review
Alkaline phosphatase · Adults with chronic kidney disease requiring dialysis
Meta-analysis of randomised trials of vitamin D supplementation for Alkaline phosphatase: WMD -27.35 (95% CI -50.69 to -4.01), statistically significant. Umbrella review outcome-level evidence grade: Suggestive.
1 finding from 1 review
Fracture · Older or community-dwelling adults
Meta-analysis of randomised trials of vitamin D supplementation for Fractures, Men aged >65 years and postmenopausal women: RR 1.01 (95% CI 0.93 to 1.09), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
Quality of life · Patients of any age in any setting requiring intervention for iatrogenic injury to the inferior alveolar or lingual nerve
The review found no eligible studies for this question.
1 finding from 1 review
Bone mineral density in forearm · Older or community-dwelling adults
Meta-analysis of randomised trials of vitamin D supplementation for Bone mineral density in forearm, Community-dwelling adults: WMD -0.70 (95% CI -1.70 to 0.40), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
WMD -0.70 [-1.70, 0.40]
2 studies
GRADE not reported
Hip/femoral bone mineral density (BMD) · Older or community-dwelling adults
Meta-analysis of randomised trials of vitamin D supplementation for Bone mineral density in hip, Community-dwelling adults: WMD 0.70 (95% CI -0.10 to 1.60), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
WMD 0.70 [-0.10, 1.60]
6 studies
GRADE not reported