Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,310 questions · 1,358 findings · 214 reviews

No studies found 230 · 16.9%GRADE not reported 169 · 12.4%Very low 269 · 19.8%Low 277 · 20.4%Moderate 291 · 21.4%High 122 · 9%

Corticosteroid creams/ointments: clobetasol propionate foam vs vehicle foam

Primary: adverse events ‐ any adverse event treatment‐related (application site pruritus) · participants with moderate to severe hand eczema

Corticosteroid creams/ointments: clobetasol propionate foam showed no clear difference in primary: adverse events ‐ any adverse event treatment‐related… compared with vehicle foam (moderate certainty).

1 finding from 1 review

Corticosteroid creams/ointments: clobetasol propionate foam vs vehicle foam

Secondary: reduction in severity, participant‐rated scoring · participants with moderate to severe hand eczema

Corticosteroid creams/ointments: clobetasol propionate foam probably leads to higher secondary: reduction in severity, participant‐rated scoring compared with vehicle foam (moderate certainty).

1 finding from 1 review

Corticosteroid creams/ointments: clobetasol propionate foam vs vehicle foam

Secondary: reduction in severity, investigator‐rated scoring ‐ improvement at least 2 grades · participants with moderate to severe hand eczema

Corticosteroid creams/ointments: clobetasol propionate foam showed no clear difference in secondary: reduction in severity, investigator‐rated scoring ‐… compared with vehicle foam (moderate certainty).

1 finding from 1 review