Colorectal cancer · Adults (general population)
Meta-analysis of observational studies (higher vs lower 25(OH)D) for Colorectal cancer: RR 0.70 (95% CI 0.58 to 0.84), statistically significant. Umbrella review outcome-level evidence grade: Suggestive.
1 finding from 1 review
Alteration of hyperdivergent growth pattern · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…
1 finding from 1 review
CVD · Adults (general population)
Meta-analysis of observational studies (higher vs lower 25(OH)D) for Cardiovascular disease: RR 0.66 (95% CI 0.57 to 0.77), statistically significant. Umbrella review outcome-level evidence grade: Suggestive.
1 finding from 1 review
Economic evaluation (costs) · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…
The review found no eligible studies for this question.
1 finding from 1 review
Depression · Adults (general population)
Meta-analysis of observational studies (higher vs lower 25(OH)D) for Depression (Cohort studies): HR 0.44 (95% CI 0.27 to 0.72), statistically significant. Umbrella review outcome-level evidence grade: Suggestive.
2 findings from 1 review
Implant failure · Adults with missing teeth who received osseointegrated root-formed oral implants, functionally loaded and followed for at least 1 year
Steri-Oss acid-etched titanium screws showed no clear difference in implant failure compared with southern blasted/etched titanium screws; GRADE not reported.
1 finding from 1 review
Implant failure · Adults with missing teeth who received osseointegrated root-formed oral implants, functionally loaded and followed for at least 1 year
Southern regular implants showed no clear difference in implant failure compared with neoss turned implants; GRADE not reported.
1 finding from 1 review
Implant failure · Adults with missing teeth who received osseointegrated root-formed oral implants, functionally loaded and followed for at least 1 year
1 finding from 1 review
Breast cancer · Adults (general population)
Meta-analysis of observational studies (higher vs lower 1,25(OH)2D) for Breast cancer: OR 0.99 (95% CI 0.68 to 1.44), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
Ischaemic stroke · Adults (general population)
Meta-analysis of observational studies (higher vs lower 25(OH)D) for Ischaemic stroke (Hazard ratio (cohort studies)): HR 0.66 (95% CI 0.55 to 0.80), statistically significant. Umbrella review outcome-level evidence grade: Suggestive.
2 findings from 1 review
Colon cancer · Adults (general population)
Meta-analysis of observational studies (higher vs lower 1,25(OH)2D) for Colon cancer: OR 0.88 (95% CI 0.57 to 1.35), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
OR 0.88 [0.57, 1.35]
4 studies
GRADE not reported
Implant failure · Adults with missing teeth who received osseointegrated root-formed oral implants, functionally loaded and followed for at least 1 year
1 finding from 1 review
Aggressive prostate cancer · Adults (general population)
Meta-analysis of observational studies (higher vs lower 1,25(OH)2D) for Aggressive prostate cancer: OR 0.75 (95% CI 0.48 to 1.17), not statistically significant. Umbrella review outcome-level evidence grade: Substantial effect unlikely.
1 finding from 1 review
Gestational diabetes · pregnant women and their infants..
Meta-analysis of observational studies (higher vs lower maternal 25(OH)D) for Gestational diabetes: OR 0.67 (95% CI 0.53 to 0.85), statistically significant. Umbrella review outcome-level evidence grade: Suggestive.
1 finding from 1 review
Reduction of snoring · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…
The review found no eligible studies for this question.
1 finding from 1 review
Anterior open bite correction · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…
1 finding from 1 review
Orthodontic and orthopaedic treatment for anterior open bite in children 2014 · Cochrane All outcomesAbout 4 months (treatment interrupted early)
Could not be analysed statistically. After 4 months the open bite was observed to close in the magnet group, but in four out of these ten patients transverse problems (unilateral crossbite) were observed, which led to…
1 study
GRADE not reported
Implant failure · Adults with missing teeth who received osseointegrated root-formed oral implants, functionally loaded and followed for at least 1 year
NobelActive external connection implants showed no clear difference in implant failure compared with nobelActive internal connection implants; GRADE not reported.
1 finding from 1 review
Prostate cancer · Adults (general population)
Meta-analysis of observational studies (higher vs lower 1,25(OH)2D) for Prostate cancer: OR 0.99 (95% CI 0.87 to 1.14), not statistically significant. Umbrella review outcome-level evidence grade: Substantial effect unlikely.
1 finding from 1 review
Kidney cancer · Adults (general population)
Meta-analysis of observational studies (higher vs lower 25(OH)D) for Kidney cancer: OR 1.01 (95% CI 0.65 to 1.58), not statistically significant. Umbrella review outcome-level evidence grade: Substantial effect unlikely.
1 finding from 1 review
Implant failure · Patients with insufficient bone below the maxillary sinus requiring dental implants
1 finding from 1 review
No statistically significant difference for implant failures. Per trial: Raghoebar 2005 1 failure in the PRP arm, OR 3.67 (0.12 to 113.73), P = 0.46; Torres 2009 (PRP only = 1, no-PRP only = 2), OR 0.50 (0.01 to…
2 studies · 62 participants
GRADE not reported