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Evidence found and GRADE certainty

1,078 questions · 1,098 findings · 33 reviews · Skin

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No studies found 396 · 36.1%GRADE not reported 89 · 8.1%Very low 181 · 16.5%Low 183 · 16.7%Moderate 196 · 17.9%High 53 · 4.8%

Adalimumab weekly vs placebo

Treatment discontinuation · participants with hidradenitis suppurativa

Adalimumab weekly showed no clear difference in frequency of treatment discontinuation compared with placebo (moderate certainty).

1 finding from 1 review

Staphage lysate vs placebo broth

Physician Global Assessment (Thongprasom score) · participants with hidradenitis suppurativa

Staphage lysate probably leads to higher physician global assessment compared with placebo broth (moderate certainty).

1 finding from 1 review

Adalimumab weekly vs placebo

Proportion of participants with infectious adverse effects · participants with hidradenitis suppurativa

Adalimumab weekly showed no clear difference in proportion of participants with infectious adverse effects compared with placebo (moderate certainty).

1 finding from 1 review

Adalimumab weekly vs placebo

Proportion with improvement in pain VAS · participants with hidradenitis suppurativa

Adalimumab weekly probably leads to higher proportion with improvement in pain VAS compared with placebo (moderate certainty).

1 finding from 1 review

Adalimumab every other week vs placebo

Frequency of serious adverse effects · participants with hidradenitis suppurativa

Adalimumab every other week showed no clear difference in frequency of serious adverse effects compared with placebo (high certainty).

1 finding from 1 review

Oral aciclovir (short‐term) vs placebo

Incidence of herpes labialis after use of the preventative intervention · participants with recurrent herpes labialis

Oral aciclovir (short‐term) showed no clear difference in incidence of herpes labialis during use of the preventative… compared with placebo (moderate certainty).

1 finding from 1 review

Valaciclovir (short‐term) vs placebo

Incidence of herpes labialis after use of the preventative intervention · participants with recurrent herpes labialis

Valaciclovir (short‐term) showed no clear difference in incidence of HSL during use of the preventative intervention (by… compared with placebo (moderate certainty).

1 finding from 1 review

Valaciclovir (short‐term) vs placebo

Incidence of HSL during use of the preventative intervention (by culture) · participants with recurrent herpes labialis

Valaciclovir (short‐term) showed no clear difference in incidence of HSL during use of the preventative intervention (by… compared with placebo (moderate certainty).

1 finding from 1 review

Valaciclovir (short‐term) vs placebo

Adverse effects during use of the preventative intervention · participants with recurrent herpes labialis

Valaciclovir (short‐term) showed no clear difference in adverse effects during use of the preventative intervention compared with placebo (moderate certainty).

1 finding from 1 review