Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,171 questions · 1,373 findings · 60 reviews · Dental caries

No studies found 282 · 20.5%GRADE not reported 606 · 44.1%Very low 257 · 18.7%Low 160 · 11.7%Moderate 66 · 4.8%High 2 · 0.1%

Higher drinking-water fluoride exposure vs Lower water fluoride concentration (concurrent control)

Dental fluorosis of aesthetic concern (Dean's Index, TFI, TSIF) · Populations of all ages (mostly children) exposed to drinking water with differing fluoride concentrations

Higher water fluoride concentration (fluoridated water; natural or… may leads to higher dental fluorosis of aesthetic concern (Dean's Index, TFI, TSIF) compared with lower water fluoride concentration (concurrent control) (low certainty).

1 finding from 1 review

Xylitol sucking tablets (1 g/day) vs no treatment

Number of infants with a caries increment · Infants/young children (primary teeth; baseline about 1 to 3 years)

Xylitol sucking tablets (1 g/day) showed no clear difference in number of infants with a caries increment compared with no treatment; GRADE not reported.

1 finding from 1 review

Initiation of water fluoridation (artificial or natural) vs Low/non-fluoridated water (0.4 ppm fluoride or less)

Caries development in permanent teeth · People of all ages in a community setting; the included caries studies were all in children aged 3 to 16 years

Initiation of water fluoridation (artificial or natural) may leads to lower caries in permanent teeth (change in DMFT) compared with low/non-fluoridated water (0.4 ppm fluoride or less) (low certainty).

1 finding from 1 review

Preformed crown (any material; conventional technique or Hall Technique) vs Filling (any material; with or without complete carious tissue excavation; with or without pulp treatment)

Adverse events: gingival bleeding · Children with decayed primary molar teeth

Preformed crown (any material; conventional technique or Hall… showed no clear difference in adverse events: gingival bleeding compared with filling (any material; with or without complete carious tissue…; GRADE not reported.

2 findings from 1 review

Preformed crown (any material; conventional technique or Hall Technique) vs Filling (any material; with or without complete carious tissue excavation; with or without pulp treatment)

Satisfaction with treatment · Children with decayed primary molar teeth

The review found no eligible studies for this question.

1 finding from 1 review

Fluoride gel (topically applied; operator- or self-applied; any fluoride agent/concentration; frequency at least once a year) vs placebo or no treatment

Unacceptability of treatment (dropouts/exclusions during the trial) · Children and adolescents aged 16 years or less

Fluoride gel (topically applied; operator- or self-applied; any… showed no clear difference in unacceptability of treatment (dropouts/exclusions during the trial) compared with placebo or no treatment; GRADE not reported.

3 findings from 1 review

Single full-coverage metal-ceramic crown over composite core and post vs Direct adhesive composite restoration with post (conventional filling, no crown)

Patient satisfaction / quality of life (validated measure) · People with a permanent tooth that has undergone endodontic (root canal) treatment

The review found no eligible studies for this question.

1 finding from 1 review

Preformed crown (any material; conventional technique or Hall Technique) vs Filling (any material; with or without complete carious tissue excavation; with or without pulp treatment)

Pain · Children with decayed primary molar teeth

Preformed crown (any material; conventional technique or Hall… probably leads to lower pain compared with filling (any material; with or without complete carious tissue… (moderate certainty).

2 findings from 1 review

Glass ionomer sealant (with fluoride gel plus dentifrice) vs Fluoride gel plus fluoride toothpaste/dentifrice (non-invasive control)

Caries (lesion) progression (radiographic) · Dentate children and adults with non-cavitated proximal caries lesions extending into enamel or dentine (not pulp) in primary or permanent…

Glass ionomer sealant (with fluoride gel plus dentifrice) showed no clear difference in caries (lesion) progression (radiographic) compared with fluoride gel plus fluoride toothpaste/dentifrice (non-invasive…; GRADE not reported.

1 finding from 1 review

Xylitol syrup (high dose, 8 g/day) vs Control (low-dose xylitol, 2.67 g/day) syrup

Adverse effects (loose stools, diarrhoea) · Infants (primary teeth; baseline about 9 to 15 months)
1 finding from 1 review

Cessation of water fluoridation (fluoride removed from the water supply) vs Continued fluoridated water

Change in proportion of caries-free children (deciduous or permanent teeth) · People of all ages in a previously fluoridated community (Maupome 2001: children with generally low caries experience)

The review found no eligible studies for this question.

1 finding from 1 review

Preformed crown (any material; conventional technique or Hall Technique) vs No treatment

Outcome not reported · Children with decayed primary molar teeth

The review found no eligible studies for this question.

1 finding from 1 review
  • Crown versus no treatment was a planned comparison (Comparison 2: crown versus no crown or filling). No study evaluated crown versus no treatment; the only study in this comparison (Santamaria 2014) used active…
    0 studies
    No studies found

Chlorhexidine varnish vs placebo or no treatment

Adverse events (e.g. ulcers, tooth staining) · Children and adolescents below 18 years at study start (included studies: children from birth to 15 years), with mixed, permanent or…
1 finding from 1 review