Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

954 questions · 963 findings · 130 reviews · Headline outcomes only

No studies found 181 · 18.8%GRADE not reported 71 · 7.4%Very low 163 · 16.9%Low 311 · 32.3%Moderate 163 · 16.9%High 74 · 7.7%

Sugammadex (any dose) vs neostigmine (any dose)

Number of patients with postoperative nausea and vomiting (24 hours postoperatively) · Adult patients, ASA I‐IV, who received non‐depolarizing NMBAs

Sugammadex (any dose) may leads to lower PONV compared with neostigmine (any dose) (low certainty).

1 finding from 1 review

Sugammadex (any dose) vs neostigmine (any dose)

Overall signs of postoperative residual paralysis · Adult patients, ASA I‐IV, who received non‐depolarizing NMBAs

Sugammadex (any dose) probably leads to lower overall signs of postoperative residual paralysis compared with neostigmine (any dose) (moderate certainty).

1 finding from 1 review

Sugammadex 2.0 mg/kg vs neostigmine (any dose)

Risk of adverse events and serious adverse eventsb, bradycardia, PONV, and signs of residual neuromuscular blockade · Adult patients, ASA I‐IV, who received non‐depolarizing NMBAs

The review found no eligible studies for this question.

1 finding from 1 review

Sugammadex 4.0 mg/kg vs neostigmine (any dose)

Risk of adverse events and serious adverse eventsb, bradycardia, PONV, and signs of residual neuromuscular blockade · Adult patients, ASA I‐IV, who received non‐depolarizing NMBAs

The review found no eligible studies for this question.

1 finding from 1 review

Sugammadex (any dose) vs neostigmine (any dose)

Risk of composite adverse eventsb · Adult patients, ASA I‐IV, who received non‐depolarizing NMBAs

Sugammadex (any dose) probably leads to lower risk of composite adverse eventsb compared with neostigmine (any dose) (moderate certainty).

1 finding from 1 review

Ablation vs antiarrhythmic drug

Cardiac hospitalisation Hospitalisations directly related to ablation or antiarrhythmic drugs · people with non‐paroxysmal atrial fibrillation

Ablation may leads to lower cardiac hospitalisation Hospitalisations directly related to… compared with antiarrhythmic drug (low certainty).

1 finding from 1 review