Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

970 questions · 979 findings · 135 reviews

No studies found 182 · 18.6%GRADE not reported 84 · 8.6%Very low 165 · 16.9%Low 311 · 31.8%Moderate 163 · 16.6%High 74 · 7.6%

PCT vs non‐PCT (standard care or CRP: primary outcomes)

Mortality at 28 days · adult patients with sepsis, severe sepsis and septic shock

PCT showed no clear difference in mortality at 28 days compared with non‐PCT (standard care or CRP: primary outcomes) (low certainty).

1 finding from 1 review

PCT vs non‐PCT (standard care or CRP: primary outcomes)

Mortality at ICU discharge · adult patients with sepsis, severe sepsis and septic shock

PCT showed no clear difference in mortality at ICU discharge compared with non‐PCT (standard care or CRP: primary outcomes) (low certainty).

1 finding from 1 review

PCT vs non‐PCT (standard care or CRP: primary outcomes)

Death at hospital discharge · adult patients with sepsis, severe sepsis and septic shock

PCT showed no clear difference in mortality at hospital discharge compared with non‐PCT (standard care or CRP: primary outcomes) (moderate certainty).

1 finding from 1 review