Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,066 questions · 1,120 findings · 99 reviews

No studies found 277 · 24.7%GRADE not reported 119 · 10.6%Very low 292 · 26.1%Low 274 · 24.5%Moderate 112 · 10%High 46 · 4.1%

Antioxidants vs placebo

Global impression of deterioration (investigator defined global impression of deterioration) · people with multiple sclerosis

Antioxidant showed no clear difference in global impression of deterioration (investigator defined global… compared with placebo (low certainty).

1 finding from 1 review

Antioxidants vs placebo

Number of participants with gadolinium‐enhancing T1 lesions on MRI · people with multiple sclerosis

It is very uncertain whether antioxidant changes MRI activity(assessed as number of participants with… compared with placebo (very low certainty).

1 finding from 1 review

PUFA vs monounsaturated fatty acid (MUFA)

Global impression of deterioration (investigator defined global impression of deterioration) · people with multiple sclerosis

Polyunsaturated fatty acid (PUFA) showed no clear difference in global impression of deterioration (investigator defined global… compared with monounsaturated fatty acid (MUFA) (low certainty).

1 finding from 1 review