Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,156 questions · 1,179 findings · 198 reviews · Headline outcomes only

No studies found 250 · 21.2%GRADE not reported 43 · 3.6%Very low 236 · 20%Low 395 · 33.5%Moderate 208 · 17.6%High 47 · 4%

Phenobarbital vs levetiracetam

Proportion of infants who develop sedation or drowsiness · neonates with EEG‐confirmed seizures

It is very uncertain whether summary of findings table ‐ Phenobarbital changes proportion of infants who develop sedation or drowsiness compared with levetiracetam (very low certainty).

1 finding from 1 review

Phenobarbital vs levetiracetam

Proportion of infants who develop epilepsy post‐discharge · neonates with EEG‐confirmed seizures

It is very uncertain whether summary of findings table ‐ Phenobarbital changes proportion of infants who develop epilepsy post‐discharge compared with levetiracetam (very low certainty).

1 finding from 1 review

Phenobarbital vs levetiracetam

Proportion of infants who achieve seizure control after the first loading dose of ASM · neonates with clinically diagnosed seizures

It is very uncertain whether summary of findings table ‐ Phenobarbital changes proportion of infants who achieve seizure control after first… compared with levetiracetam (very low certainty).

1 finding from 1 review

Phenobarbital vs levetiracetam

Proportion of infants who achieve seizure control after maximal loading dose of ASM · neonates with clinically diagnosed seizures

It is very uncertain whether summary of findings table ‐ Phenobarbital changes proportion of infants who achieve seizure control after maximal… compared with levetiracetam (very low certainty).

1 finding from 1 review

Digital adherence interventions vs usual care

Unscheduled healthcare utilisation ‐ number of hospital or GP/ED visits · people with asthma

Digital adherence interventions showed no clear difference in unscheduled healthcare utilisation ‐ number of hospital or GP/ED… compared with usual care (low certainty).

1 finding from 1 review

Clobazam (low, medium and high doses) plus ASMs vs placebo plus ASMs

Number of participants with adverse events leading to study discontinuation · Lennox‐Gastaut syndrome, any age

Clobazam (low, medium and high doses) plus ASMs leads to higher number of participants with adverse events leading to study… compared with placebo plus ASMs (high certainty).

1 finding from 1 review

Felbamate plus ASMs vs placebo plus ASMs

Number of participants free from all seizures (recorded by closed‐circuit television and electroencephalography) ‐ · Lennox‐Gastaut syndrome, any age

Felbamate plus ASMs showed no clear difference in number of participants free from all seizures (recorded by… compared with placebo plus ASMs (low certainty).

1 finding from 1 review

Felbamate plus ASMs vs placebo plus ASMs

Number of participants with adverse events leading to study discontinuation · Lennox‐Gastaut syndrome, any age

Felbamate plus ASMs showed no clear difference in number of participants with adverse events leading to study… compared with placebo plus ASMs (low certainty).

1 finding from 1 review