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Evidence found and GRADE certainty

1,057 questions · 1,077 findings · 32 reviews · Skin

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No studies found 395 · 36.7%GRADE not reported 89 · 8.3%Very low 172 · 16%Low 177 · 16.4%Moderate 191 · 17.7%High 53 · 4.9%

Doxycycline 40 mg + azelaic acid gel vs doxycycline 40 mg + metronidazole gel

Participant‐assessed improvement in rosacea severity · Participants with rosacea

Doxycycline 40 mg + azelaic acid gel showed no clear difference in participant‐assessed improvement in rosacea severity Excellent… compared with doxycycline 40 mg + metronidazole gel (high certainty).

1 finding from 1 review

Adalimumab every other week vs placebo

Treatment discontinuation · participants with hidradenitis suppurativa

Adalimumab every other week showed no clear difference in frequency of treatment discontinuation compared with placebo (high certainty).

1 finding from 1 review

Adalimumab every other week vs placebo

Proportion of participants with infectious adverse effects · participants with hidradenitis suppurativa

Adalimumab every other week showed no clear difference in proportion of participants with infectious adverse effects compared with placebo (high certainty).

1 finding from 1 review

Adalimumab every other week vs placebo

Proportion with improvement in pain · participants with hidradenitis suppurativa

Adalimumab every other week showed no clear difference in proportion with improvement in pain compared with placebo (moderate certainty).

1 finding from 1 review

Infliximab vs placebo

At least 50% decrease in HS Severity Index · participants with hidradenitis suppurativa

Infliximab showed no clear difference in at least 50% decrease in HS Severity Index compared with placebo (moderate certainty).

1 finding from 1 review

Infliximab vs placebo

Physician Global Assessment (Thongprasom score) · participants with hidradenitis suppurativa

Infliximab probably leads to higher physician global assessment compared with placebo (moderate certainty).

1 finding from 1 review

Topical clindamycin vs placebo

Adverse effects (non‐serious) · participants with hidradenitis suppurativa

Topical clindamycin showed no clear difference in adverse effects (non‐serious) compared with placebo (moderate certainty).

1 finding from 1 review