What do systematic reviews say?

Ketoconazole vs steroids

Ketoconazole showed no clear difference in failure to achieve complete resolution (combined for face and scalp)… compared with steroids (low certainty).

• Topical antifungals for seborrhoeic dermatitis 2015 · Cochrane Headline outcomes only
  RR 1.17 [0.95, 1.44]
  6 studies · 302 participants
  Low

Ketoconazole vs steroids

• Topical antifungals for seborrhoeic dermatitis 2015 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 80 participants
  Very low

Ketoconazole vs steroids

Ketoconazole probably leads to lower side effects (combined for face and scalp) Self report compared with steroids (moderate certainty).

• Topical antifungals for seborrhoeic dermatitis 2015 · Cochrane Headline outcomes only
  RR 0.56 [0.32, 0.96]
  8 studies · 596 participants
  Moderate

Tacrolimus 0.1% vs corticosteroids

Tacrolimus 0.1% probably leads to higher physician's assessment of global response of improvement, clear or… compared with corticosteroids (moderate certainty).

• Topical tacrolimus for atopic dermatitis 2015 · Cochrane Headline outcomes only
  RR 3.09 [2.14, 4.45]
  1 study · 371 participants
  Moderate
• Topical tacrolimus for atopic dermatitis 2015 · Cochrane Headline outcomes only
  RR 0.95 [0.78, 1.16]
  1 study · 377 participants
  Low
• Topical tacrolimus for atopic dermatitis 2015 · Cochrane Headline outcomes only
  RR 1.32 [1.17, 1.49]
  1 study · 972 participants
  Moderate

Tacrolimus 0.03% vs corticosteroids

Tacrolimus 0.03% probably leads to higher participant's self‐assessment of global response of improvement:… compared with corticosteroids (moderate certainty).

• Topical tacrolimus for atopic dermatitis 2015 · Cochrane Headline outcomes only
  RR 1.64 [1.41, 1.9]
  1 study · 416 participants
  Moderate

Tacrolimus 0.1% vs corticosteroids

Tacrolimus 0.1% probably leads to higher adverse effects: burning ‐ tacrolimus 0.1% versus hydrocortisone… compared with corticosteroids (moderate certainty).

• Topical tacrolimus for atopic dermatitis 2015 · Cochrane Headline outcomes only
  RR 2.91 [1.6, 5.28]
  1 study · 371 participants
  Moderate
• Topical tacrolimus for atopic dermatitis 2015 · Cochrane Headline outcomes only
  RR 4.59 [3.1, 6.78]
  1 study · 377 participants
  Moderate
• Topical tacrolimus for atopic dermatitis 2015 · Cochrane Headline outcomes only
  RR 3.79 [2.99, 4.81]
  1 study · 972 participants
  Moderate

Tacrolimus 0.1% vs corticosteroids

Tacrolimus 0.1% may leads to higher participant's self‐assessment of global response of improvement compared with corticosteroids (low certainty).

• Topical tacrolimus for atopic dermatitis 2015 · Cochrane Headline outcomes only
  RR 1.21 [1.13, 1.29]
  1 study · 974 participants
  Low

Intra-articular injection of sodium hyaluronate vs corticosteroid injection

Intra-articular injection of sodium hyaluronate showed no clear difference in complications (adverse effects) compared with intra-articular injection of corticosteroids (betamethasone); GRADE not reported.

• Interventions for managing temporomandibular joint osteoarthritis 2012 · Cochrane All outcomes
  RR 1.20 [0.44, 3.30]
  1 study · 40 participants
  GRADE not reported

Intra-articular injection of sodium hyaluronate vs corticosteroid injection

Intra-articular injection of sodium hyaluronate led to lower presence of TMJ sounds compared with intra-articular injection of corticosteroids (betamethasone); GRADE not reported.

• Interventions for managing temporomandibular joint osteoarthritis 2012 · Cochrane All outcomes

  14 days
  RR 0.59 [0.37, 0.95]
  1 study · 40 participants
  GRADE not reported

Intra-articular injection of sodium hyaluronate vs corticosteroid injection

Intra-articular injection of sodium hyaluronate led to lower pain on palpation of the affected/contralateral TMJ and masticatory… compared with intra-articular injection of corticosteroids (betamethasone); GRADE not reported.

• Interventions for managing temporomandibular joint osteoarthritis 2012 · Cochrane All outcomes

  14 days to 6 months
  Pain on palpation of the affected and contralateral TMJ and masticatory muscles presented similar frequencies regardless of the time (Analyses 1.4-1.12); no statistically significant differences reported. Point…
  1 study · 40 participants
  GRADE not reported

Intra-articular injection of sodium hyaluronate vs corticosteroid injection

Intra-articular injection of sodium hyaluronate showed no clear difference in extent of mandibular movement (maximum jaw opening, lateral and… compared with intra-articular injection of corticosteroids (betamethasone); GRADE not reported.

• Interventions for managing temporomandibular joint osteoarthritis 2012 · Cochrane All outcomes

  14 days to 6 months
  None of the mean differences between interventions for the measures of jaw movements (maximum jaw opening, lateral movement to affected side, contralateral movement, jaw protrusion; Analyses 1.16-1.27) showed…
  1 study · 40 participants
  GRADE not reported

Intra-articular injection of sodium hyaluronate vs corticosteroid injection

Intra-articular injection of sodium hyaluronate led to lower reported pain (mm on VAS) compared with intra-articular injection of corticosteroids (betamethasone); GRADE not reported.

• Interventions for managing temporomandibular joint osteoarthritis 2012 · Cochrane All outcomes

  6 months
  MD -17.00 [-32.60, -1.40]
  1 study · 40 participants
  GRADE not reported

Primary surgical intervention (curettage, peripheral osteotomy, or resection) vs Primary non-surgical intervention (intralesional corticosteroids, subcutaneous calcitonin, interferon alpha, or imatinib)

The review found no eligible studies for this question.

• Interventions for central giant cell granuloma (CGCG) of the jaws 2009 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Primary surgical intervention (curettage, peripheral osteotomy, or resection) vs Primary non-surgical intervention (intralesional corticosteroids, subcutaneous calcitonin, interferon alpha, or imatinib)

The review found no eligible studies for this question.

• Interventions for central giant cell granuloma (CGCG) of the jaws 2009 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Primary surgical intervention (curettage, peripheral osteotomy, or resection) vs Primary non-surgical intervention (intralesional corticosteroids, subcutaneous calcitonin, interferon alpha, or imatinib)

The review found no eligible studies for this question.

• Interventions for central giant cell granuloma (CGCG) of the jaws 2009 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Primary surgical intervention (curettage, peripheral osteotomy, or resection) vs Primary non-surgical intervention (intralesional corticosteroids, subcutaneous calcitonin, interferon alpha, or imatinib)

The review found no eligible studies for this question.

• Interventions for central giant cell granuloma (CGCG) of the jaws 2009 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Primary surgical intervention (curettage, peripheral osteotomy, or resection) vs Primary non-surgical intervention (intralesional corticosteroids, subcutaneous calcitonin, interferon alpha, or imatinib)

The review found no eligible studies for this question.

• Interventions for central giant cell granuloma (CGCG) of the jaws 2009 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Primary surgical intervention (curettage, peripheral osteotomy, or resection) vs Primary non-surgical intervention (intralesional corticosteroids, subcutaneous calcitonin, interferon alpha, or imatinib)

The review found no eligible studies for this question.

• Interventions for central giant cell granuloma (CGCG) of the jaws 2009 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Primary surgical intervention (curettage, peripheral osteotomy, or resection) vs Primary non-surgical intervention (intralesional corticosteroids, subcutaneous calcitonin, interferon alpha, or imatinib)

The review found no eligible studies for this question.

• Interventions for central giant cell granuloma (CGCG) of the jaws 2009 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Primary surgical intervention (curettage, peripheral osteotomy, or resection) vs Primary non-surgical intervention (intralesional corticosteroids, subcutaneous calcitonin, interferon alpha, or imatinib)

The review found no eligible studies for this question.

• Interventions for central giant cell granuloma (CGCG) of the jaws 2009 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found