Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,106 questions · 1,152 findings · 69 reviews

No studies found 216 · 18.8%GRADE not reported 448 · 38.9%Very low 122 · 10.6%Low 195 · 16.9%Moderate 127 · 11%High 44 · 3.8%

Morphine via pharmacokinetically based PCA (PKPCA) vs Morphine via patient-controlled analgesia (PCA)

Average pain scores (0-100 VAS) · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis

Morphine via pharmacokinetically based PCA (PKPCA) led to lower average pain scores (0-100 VAS) compared with morphine via patient-controlled analgesia (PCA); GRADE not reported.

1 finding from 1 review

Any antifungal intervention for the treatment of oral candidiasis vs Placebo, no treatment, or another active antifungal intervention

Relief of pain · Patients with cancer receiving chemotherapy and/or radiotherapy with overt oral candidiasis

The review found no eligible studies for this question.

1 finding from 1 review

Benzydamine hydrochloride mouthwash vs placebo

Improvement in mucositis · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis

Benzydamine hydrochloride mouthwash showed no clear difference in improvement in mucositis compared with placebo; GRADE not reported.

1 finding from 1 review

Morphine via patient-controlled analgesia (PCA) vs Morphine via continuous infusion (CI)

Duration of pain control therapy (days) · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis

Morphine via patient-controlled analgesia (PCA) led to lower duration of pain control therapy (days) compared with morphine via continuous infusion (CI); GRADE not reported.

1 finding from 1 review

Fluconazole (absorbed from GI tract) vs Ketoconazole (absorbed from GI tract)

Clinical: eradication of oral candidiasis · Patients with cancer receiving chemotherapy and/or radiotherapy with overt oral candidiasis

Fluconazole (absorbed from GI tract) showed no clear difference in clinical: eradication of oral candidiasis compared with ketoconazole (absorbed from GI tract); GRADE not reported.

1 finding from 1 review

Any antifungal intervention for the treatment of oral candidiasis vs Placebo, no treatment, or another active antifungal intervention

Patient quality of life · Patients with cancer receiving chemotherapy and/or radiotherapy with overt oral candidiasis

The review found no eligible studies for this question.

1 finding from 1 review

Morphine vs Tricyclic antidepressant (nortriptyline)

Average pain scores (0-100 VAS) · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis

Morphine led to lower average pain scores (0-100 VAS) compared with tricyclic antidepressant (nortriptyline); GRADE not reported.

1 finding from 1 review

Clotrimazole 50 mg (partially absorbed) vs Clotrimazole 10 mg (partially absorbed)

Mycological: eradication of oral candidiasis · Patients with cancer receiving chemotherapy and/or radiotherapy with overt oral candidiasis

Clotrimazole 50 mg (partially absorbed) led to higher mycological: eradication of oral candidiasis compared with clotrimazole 10 mg (partially absorbed); GRADE not reported.

1 finding from 1 review

GM-CSF vs povidone‐iodine

Time to heal mucositis (days) · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis

Granulocyte macrophage-colony stimulating factor (GM-CSF) led to lower time to heal mucositis (days) compared with povidone iodine; GRADE not reported.

1 finding from 1 review

Antifungal drugs partially absorbed from GI tract (miconazole, clotrimazole) vs placebo or no treatment

Systemic fungal infection · Patients with cancer receiving chemotherapy and/or radiotherapy

Antifungal drugs partially absorbed from GI tract (miconazole,… showed no clear difference in systemic fungal infection compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

Antifungal drugs not absorbed from GI tract vs placebo or no treatment

Oral candidiasis (present) · Patients with cancer receiving chemotherapy and/or radiotherapy

Antifungal drugs not absorbed from GI tract showed no clear difference in oral candidiasis (present) compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review