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Evidence found and GRADE certainty

4,776 questions · 7,311 findings · 959 reviews · Headline outcomes only

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No studies found 1,498 · 20.5%GRADE not reported 303 · 4.1%Very low 1,839 · 25.2%Low 1,991 · 27.2%Moderate 1,277 · 17.5%High 403 · 5.5%

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CHLORPROMAZINE LOW DOSE (≤ 400 mg/day) vs MEDIUM DOSE (401 mg/day to 800 mg/day)

Behaviour: agitation and restlessness ‐ medium term (categorised as adverse event) · patients with schizophrenia

It is very uncertain whether CHLORPROMAZINE LOW DOSE (≤ 400 mg/day) changes behaviour: agitation and restlessness ‐ medium term (categorised as… compared with MEDIUM DOSE (401 mg/day to 800 mg/day) (very low certainty).

1 finding from 1 review

CHLORPROMAZINE LOW DOSE (≤ 400 mg/day) vs MEDIUM DOSE (401 mg/day to 800 mg/day)

Adverse effects: any observed extrapyramidal symptoms ‐ short term (up to 6 months) · patients with schizophrenia

CHLORPROMAZINE LOW DOSE (≤ 400 mg/day) probably leads to lower adverse effects: extrapyramidal symptoms (unspecified extrapyramidal… compared with MEDIUM DOSE (401 mg/day to 800 mg/day) (moderate certainty).

1 finding from 1 review

CHLORPROMAZINE LOW DOSE (≤ 400 mg/day) vs HIGH DOSE (> 800 mg/day ‐ all medium term)

Global state: No clinically significant response (as defined by the original studies) · schizophrenia

CHLORPROMAZINE LOW DOSE (≤ 400 mg/day) probably leads to higher global state: no clinically important improvement ‐ medium term compared with HIGH DOSE (> 800 mg/day ‐ all medium term) (moderate certainty).

1 finding from 1 review

Chemotherapy plus lower‐dose radiation vs same chemotherapy plus higher‐dose radiation

Secondary malignant neoplasms · Patients with untreated Hodgkin lymphoma (early stages)

Chemotherapy plus lower‐dose radiation showed no clear difference in secondary malignant neoplasms compared with same chemotherapy plus higher‐dose radiation (low certainty).

1 finding from 1 review

Chemotherapy plus lower‐dose radiation vs same chemotherapy plus higher‐dose radiation

Death · Patients with untreated Hodgkin lymphoma (early stages)

Chemotherapy plus lower‐dose radiation showed no clear difference in death compared with same chemotherapy plus higher‐dose radiation (high certainty).

1 finding from 1 review

Chemotherapy plus lower‐dose radiation vs same chemotherapy plus higher‐dose radiation

Progression/relapse · Patients with untreated Hodgkin lymphoma (early stages)

Chemotherapy plus lower‐dose radiation showed no clear difference in progression/relapse compared with same chemotherapy plus higher‐dose radiation (high certainty).

1 finding from 1 review

Waterlow pressure ulcer risk assessment vs Ramstadius pressure ulcer risk assessment

Proportion of participants developing a new pressure ulcer · individuals at risk of pressure ulcer development

Waterlow pressure ulcer risk assessment showed no clear difference in pressure ulcer incidence Visual skin assessment compared with ramstadius pressure ulcer risk assessment (low certainty).

1 finding from 1 review

Waterlow pressure ulcer risk assessment vs Ramstadius pressure ulcer risk assessment

Severity of new pressure ulcers ‐ Stage 1 · individuals at risk of pressure ulcer development

Waterlow pressure ulcer risk assessment showed no clear difference in severity of new pressure ulcers ‐ Stage 1 compared with ramstadius pressure ulcer risk assessment (low certainty).

1 finding from 1 review

Waterlow pressure ulcer risk assessment vs Ramstadius pressure ulcer risk assessment

Severity of new pressure ulcers ‐ Stage 2 · individuals at risk of pressure ulcer development

Waterlow pressure ulcer risk assessment showed no clear difference in severity of new pressure ulcers ‐ Stage 2 compared with ramstadius pressure ulcer risk assessment (low certainty).

1 finding from 1 review

Waterlow pressure ulcer risk assessment vs pressure ulcer risk assessment using clinical judgement

Proportion of participants developing a new pressure ulcer · individuals at risk of pressure ulcer development

Waterlow pressure ulcer risk assessment showed no clear difference in pressure ulcer incidence Visual skin assessment compared with pressure ulcer risk assessment using clinical judgement (low certainty).

1 finding from 1 review

Waterlow pressure ulcer risk assessment vs pressure ulcer risk assessment using clinical judgement

Severity of new pressure ulcers ‐ Stage 1 · individuals at risk of pressure ulcer development

Waterlow pressure ulcer risk assessment showed no clear difference in severity of new pressure ulcers ‐ Stage 1 compared with pressure ulcer risk assessment using clinical judgement (low certainty).

1 finding from 1 review

Waterlow pressure ulcer risk assessment vs pressure ulcer risk assessment using clinical judgement

Severity of new pressure ulcers ‐ Stage 2 · individuals at risk of pressure ulcer development

Waterlow pressure ulcer risk assessment showed no clear difference in severity of new pressure ulcers ‐ Stage 2 compared with pressure ulcer risk assessment using clinical judgement (low certainty).

1 finding from 1 review

Summary of findings: Low‐moderate GI diet vs moderate‐high GI diet (maternal outcomes)

Hypertensive disorders of pregnancy: severe hypertension or pre‐eclampsia · pregnant women with GDM

It is very uncertain whether summary of findings: Low‐moderate GI diet changes hypertensive disorders of pregnancy: severe hypertension or… compared with moderate‐high GI diet (maternal outcomes) (very low certainty).

1 finding from 1 review