Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,361 questions · 1,518 findings · 352 reviews

No studies found 73 · 4.8%GRADE not reported 211 · 13.9%Very low 500 · 32.9%Low 411 · 27.1%Moderate 252 · 16.6%High 71 · 4.7%

Serotonin and noradrenaline reuptake inhibitors (SNRI) vs placebo

Participant‐reported sleep problems (scale: 0 to 28; higher scores indicate more sleep problems) · patients with fibromyalgia

Serotonin noradrenaline reuptake inhibitors showed no clear difference in self‐reported sleep problems (0‐100 scale) Higher scores indicate… compared with placebo (low certainty).

1 finding from 1 review

Serotonin and noradrenaline reuptake inhibitors (SNRI) vs placebo

Self‐reported health‐related quality of life (0‐100 scale) Higher scores indicate higher burden of disease (lower quality of life) · patients with fibromyalgia

Serotonin noradrenaline reuptake inhibitors showed no clear difference in self‐reported health‐related quality of life (0‐100 scale) Higher… compared with placebo (low certainty).

1 finding from 1 review

Intervention not reported

Next‐day alertness Participant reports. Scale from: 0 to 10 points; higher scores equalled better outcome; CFB and double‐blind average values included · Patients with insomnia
1 finding from 1 review

Intervention not reported

SF‐36 social function. Domain of SF‐36 considered representative of quality of life: mental health domain largely covered by depression and anxiety above: scale of 0‐100. Higher score indicated improved social function. Mean duration of · people with chronic hip, knee or hip and knee osteoarthritis
1 finding from 1 review

Summary of findings: NBAS or NBO vs control

Caregiver knowledge (related to infants' physical capacities, including reflexes and senses) Assessed at postintervention, using multiple choice factual questions; higher scores indicate better outcome · caregiver‐infant dyads
1 finding from 1 review