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Evidence found and GRADE certainty

957 questions · 979 findings · 250 reviews

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No studies found 159 · 16.2%GRADE not reported 75 · 7.7%Very low 264 · 27%Low 303 · 30.9%Moderate 138 · 14.1%High 40 · 4.1%

Combined index tests (e.g. vital staining plus light-based detection or cytology) vs Surgical or punch biopsy with histological assessment

Sensitivity · Adults (aged 16 years or over) presenting to primary or secondary care with clinically evident suspicious or innocuous oral lesions
1 finding from 1 review

Light-based detection and/or oral spectroscopy (e.g. ViziLite, VELscope, Microlux DL, Identafi 3000) vs Surgical or punch biopsy with histological assessment

Sensitivity · Adults (aged 16 years or over) presenting to primary or secondary care with clinically evident suspicious or innocuous oral lesions
1 finding from 1 review

Brief motivational interviewing (BMI) vs assessment‐only to reduce alcohol consumption

25% reduction of drinking days in the past 30 days · concurrent problem alcohol and illicit drug users

Brief motivational interviewing (BMI) showed no clear difference in 25% reduction of drinking days in the past 30 days compared with assessment‐only to reduce alcohol consumption (moderate certainty).

1 finding from 1 review

Brief motivational interviewing (BMI) vs assessment‐only to reduce alcohol consumption

50% reduction of drinking days in the past 30 days · concurrent problem alcohol and illicit drug users

Brief motivational interviewing (BMI) showed no clear difference in 50% reduction of drinking days in the past 30 days compared with assessment‐only to reduce alcohol consumption (moderate certainty).

1 finding from 1 review

Brief motivational interviewing (BMI) vs assessment‐only to reduce alcohol consumption

or more drinking days' reduction in the past 30 days · concurrent problem alcohol and illicit drug users

Brief motivational interviewing (BMI) probably leads to higher or more drinking days' reduction in the past 30 days compared with assessment‐only to reduce alcohol consumption (moderate certainty).

1 finding from 1 review

Brief motivational interviewing (BMI) vs assessment‐only to reduce alcohol consumption

Retention [ · concurrent problem alcohol and illicit drug users

Brief motivational interviewing (BMI) showed no clear difference in retention ‐ end of treatment compared with assessment‐only to reduce alcohol consumption (moderate certainty).

1 finding from 1 review

Does treatment guided by serial BNP or NT‐proBNP monitoring improve outcomes vs treatment guided by clinical assessment alone?

All‐cause mortality · patients with heart failure

Does treatment guided by serial BNP or NT‐proBNP monitoring improve… showed no clear difference in all‐cause mortality compared with treatment guided by clinical assessment alone? (low certainty).

1 finding from 1 review

Does treatment guided by serial BNP or NT‐proBNP monitoring improve outcomes vs treatment guided by clinical assessment alone?

Heart failure mortality · patients with heart failure

Does treatment guided by serial BNP or NT‐proBNP monitoring improve… showed no clear difference in heart failure mortality compared with treatment guided by clinical assessment alone? (low certainty).

1 finding from 1 review

Does treatment guided by serial BNP or NT‐proBNP monitoring improve outcomes vs treatment guided by clinical assessment alone?

Heart failure hospitalisation (RR) · patients with heart failure

Does treatment guided by serial BNP or NT‐proBNP monitoring improve… may leads to lower heart failure admissions compared with treatment guided by clinical assessment alone? (low certainty).

1 finding from 1 review

Does treatment guided by serial BNP or NT‐proBNP monitoring improve outcomes vs treatment guided by clinical assessment alone?

Hospital admissions · patients with heart failure

Does treatment guided by serial BNP or NT‐proBNP monitoring improve… showed no clear difference in all‐cause admissions compared with treatment guided by clinical assessment alone? (low certainty).

1 finding from 1 review