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Evidence found and GRADE certainty

1,296 questions · 1,330 findings · 157 reviews · Headline outcomes only

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No studies found 297 · 22.3%GRADE not reported 88 · 6.6%Very low 327 · 24.6%Low 317 · 23.8%Moderate 239 · 18%High 62 · 4.7%

Summary of findings: continuous cycles alternating aztreonam lysine for inhalation with tobramycin for inhalation solution vs continuous cycles alternating placebo with tobramycin

FEV1 (% predicted): mean change from baseline · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen
1 finding from 1 review

Summary of findings: continuous cycles alternating aztreonam lysine for inhalation with tobramycin for inhalation solution vs continuous cycles alternating placebo with tobramycin

FVC · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings: continuous cycles alternating aztreonam lysine for inhalation with tobramycin for inhalation solution vs continuous cycles alternating placebo with tobramycin

Pulmonary exacerbations: rate of PDEs per participant year · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen

Summary of findings: continuous cycles alternating aztreonam lysine… showed no clear difference in pulmonary exacerbations: rate of PDEs per participant year compared with continuous cycles alternating placebo with tobramycin (low certainty).

1 finding from 1 review

Summary of findings: continuous cycles alternating aztreonam lysine for inhalation with tobramycin for inhalation solution vs continuous cycles alternating placebo with tobramycin

Quality of life: respiratory domain · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen
1 finding from 1 review

Summary of findings: continuous cycles alternating aztreonam lysine for inhalation with tobramycin for inhalation solution vs continuous cycles alternating placebo with tobramycin

Survival · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings: continuous cycles alternating aztreonam lysine for inhalation with tobramycin for inhalation solution vs continuous cycles alternating placebo with tobramycin

Antibiotic resistance: change from baseline in P aeruginosa CFU/g of sputum at week 24 · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen
1 finding from 1 review

Summary of findings: continuous cycles alternating aztreonam lysine for inhalation with tobramycin for inhalation solution vs continuous cycles alternating placebo with tobramycin

Adverse events: any adverse event in the comparative phase · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen

Summary of findings: continuous cycles alternating aztreonam lysine… showed no clear difference in adverse events: any adverse event in the comparative phase compared with continuous cycles alternating placebo with tobramycin (low certainty).

1 finding from 1 review

Intervention not reported

Primary ‐ Short‐term complications (abscess, perforation, obstruction or fistula) within 30 days · Patients with acute uncomplicated diverticulitis

The intervention showed no clear difference in primary ‐ Short‐term complications (abscess, perforation,… (low certainty).

1 finding from 1 review

Intervention not reported

Secondary ‐ Recurrence during · Patients with acute uncomplicated diverticulitis

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Secondary ‐ Long‐term complications during · Patients with acute uncomplicated diverticulitis

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Secondary ‐ Long‐term emergency surgery during · Patients with acute uncomplicated diverticulitis

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Secondary ‐ All‐cause mortality · Patients with acute uncomplicated diverticulitis

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Secondary ‐ Adverse events · Patients with acute uncomplicated diverticulitis

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Primary ‐ Short‐term complications (abscess, perforation, obstruction or fistula) within 30 days · Patients with acute uncomplicated diverticulitis

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Primary ‐ Short‐term emergency surgery within 30 days · Patients with acute uncomplicated diverticulitis

The review found no eligible studies for this question.

1 finding from 1 review