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Search review questions

Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

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Intervention or exposure

Comparison

Outcome

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Field or topic

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Review versions

2,206 questions in 117 reviews · Common Mental Disorders

current versions

No studies 387 · 17.5%Ungraded 111 · 5%Very low 635 · 28.8%Low 568 · 25.7%Moderate 449 · 20.4%High 56 · 2.5%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Question	Effect	Evidence	Status / GRADE
Fluoxetine vs trazodone Endpoint score (HDRS or MADRS) · patients with depression Fluoxetine versus other types of pharmacotherapy for depression (2013) · Cochrane	no estimate extracted	4 studies · 203 participants	Moderate
Fluoxetine vs trazodone Failure to complete ‐ total ‐ · patients with depression Fluoxetine versus other types of pharmacotherapy for depression (2013) · Cochrane	OR 0.51 [0.23, 1.13]	4 studies · 230 participants	Moderate
Fluoxetine vs trazodone Failure to complete ‐ inefficacy ‐ · patients with depression Fluoxetine versus other types of pharmacotherapy for depression (2013) · Cochrane	OR 0.23 [0.04, 1.51]	2 studies · 70 participants	Moderate
Fluoxetine vs trazodone Failure to complete ‐ side effects ‐ · patients with depression Fluoxetine versus other types of pharmacotherapy for depression (2013) · Cochrane	OR 0.66 [0.2, 2.19]	3 studies · 110 participants	Moderate
Fluoxetine vs venlafaxine Failure to respond (reduction ≥ 50% on HDRS) · patients with depression Fluoxetine versus other types of pharmacotherapy for depression (2013) · Cochrane	OR 1.29 [1.1, 1.51]	12 studies · 3387 participants	Moderate
Fluoxetine vs venlafaxine Endpoint score (HDRS or MADRS) · patients with depression Fluoxetine versus other types of pharmacotherapy for depression (2013) · Cochrane	no estimate extracted	13 studies · 3097 participants	Moderate
Fluoxetine vs venlafaxine Failure to complete ‐ total ‐ · patients with depression Fluoxetine versus other types of pharmacotherapy for depression (2013) · Cochrane	OR 0.89 [0.74, 1.06]	14 studies · 2683 participants	Moderate
Fluoxetine vs venlafaxine Failure to complete ‐ inefficacy ‐ · patients with depression Fluoxetine versus other types of pharmacotherapy for depression (2013) · Cochrane	OR 1.31 [0.91, 1.89]	13 studies · 2640 participants	Moderate
Fluoxetine vs agomelatine Failure to complete ‐ total ‐ · patients with depression Fluoxetine versus other types of pharmacotherapy for depression (2013) · Cochrane	OR 1.31 [0.89, 1.94]	2 studies · 785 participants	Moderate
Fluoxetine vs venlafaxine Failure to complete ‐ side effects ‐ · patients with depression Fluoxetine versus other types of pharmacotherapy for depression (2013) · Cochrane	OR 0.72 [0.56, 0.94]	13 studies · 2640 participants	Moderate
Fluoxetine vs agomelatine Failure to complete ‐ inefficacy ‐ · patients with depression Fluoxetine versus other types of pharmacotherapy for depression (2013) · Cochrane	OR 1.08 [0.41, 2.88]	2 studies · 785 participants	Moderate
Fluoxetine vs agomelatine Failure to complete ‐ side effects ‐ · patients with depression Fluoxetine versus other types of pharmacotherapy for depression (2013) · Cochrane	OR 1.51 [0.74, 3.07]	2 studies · 785 participants	Moderate
Fluoxetine vs amineptine Failure to respond (reduction ≥ 50% on HDRS) · patients with depression Fluoxetine versus other types of pharmacotherapy for depression (2013) · Cochrane	OR 0.37 [0.13, 1.04]	1 study · 63 participants	Moderate
Fluoxetine vs amineptine Endpoint score (HDRS or MADRS) · patients with depression Fluoxetine versus other types of pharmacotherapy for depression (2013) · Cochrane	no estimate extracted	0 studies · 0 participants	Ungraded
Fluoxetine vs amineptine Failure to complete ‐ total ‐ · patients with depression Fluoxetine versus other types of pharmacotherapy for depression (2013) · Cochrane	OR 0.61 [0.17, 2.21]	2 studies · 232 participants	Moderate
Fluoxetine vs amineptine Failure to complete ‐ inefficacy ‐ · patients with depression Fluoxetine versus other types of pharmacotherapy for depression (2013) · Cochrane	OR 1.04 [0.19, 5.57]	1 study · 63 participants	Moderate
Fluoxetine vs TCAs Endpoint score (HDRS or MADRS) · patients with depression Fluoxetine versus other types of pharmacotherapy for depression (2013) · Cochrane	no estimate extracted	50 studies · 3393 participants	Moderate
Fluoxetine vs amineptine Failure to complete ‐ side effects ‐ (Copy) · patients with depression Fluoxetine versus other types of pharmacotherapy for depression (2013) · Cochrane	OR 0.52 [0.03, 7.82]	2 studies · 232 participants	Moderate
Fluoxetine vs amisulpride Failure to respond (reduction ≥ 50% on HDRS) · patients with depression Fluoxetine versus other types of pharmacotherapy for depression (2013) · Cochrane	no estimate extracted	0 studies · 0 participants	Ungraded
Fluoxetine vs amisulpride Endpoint score (HDRS or MADRS) · patients with depression Fluoxetine versus other types of pharmacotherapy for depression (2013) · Cochrane	no estimate extracted	1 study · 268 participants	Low
Fluoxetine vs amisulpride Failure to complete ‐ total ‐ · patients with depression Fluoxetine versus other types of pharmacotherapy for depression (2013) · Cochrane	OR 1.39 [0.81, 2.38]	1 study · 281 participants	Low
Fluoxetine vs amisulpride Failure to complete ‐ inefficacy ‐ · patients with depression Fluoxetine versus other types of pharmacotherapy for depression (2013) · Cochrane	OR 1.16 [0.43, 3.1]	1 study · 281 participants	Low
Fluoxetine vs amisulpride Failure to complete ‐ side effects ‐ · patients with depression Fluoxetine versus other types of pharmacotherapy for depression (2013) · Cochrane	OR 0.77 [0.33, 1.82]	1 study · 281 participants	Low
Fluoxetine vs bupropion Failure to respond (reduction ≥ 50% on HDRS) · patients with depression Fluoxetine versus other types of pharmacotherapy for depression (2013) · Cochrane	OR 0.83 [0.48, 1.43]	2 studies · 436 participants	Moderate
Fluoxetine vs bupropion Endpoint score (HDRS or MADRS) · patients with depression Fluoxetine versus other types of pharmacotherapy for depression (2013) · Cochrane	no estimate extracted	0 studies · 0 participants	Ungraded
Fluoxetine vs bupropion Failure to complete ‐ total ‐ · patients with depression Fluoxetine versus other types of pharmacotherapy for depression (2013) · Cochrane	OR 1 [0.67, 1.48]	2 studies · 436 participants	Moderate
Fluoxetine vs bupropion Failure to complete ‐ inefficacy ‐ · patients with depression Fluoxetine versus other types of pharmacotherapy for depression (2013) · Cochrane	OR 1.16 [0.33, 4.1]	2 studies · 436 participants	Moderate
Fluoxetine vs TCAs Failure to complete ‐ total ‐ · patients with depression Fluoxetine versus other types of pharmacotherapy for depression (2013) · Cochrane	OR 0.79 [0.65, 0.96]	49 studies · 4194 participants	Moderate
Fluoxetine vs bupropion Failure to complete ‐ side effects ‐ · patients with depression Fluoxetine versus other types of pharmacotherapy for depression (2013) · Cochrane	OR 1.01 [0.45, 2.25]	2 studies · 436 participants	Moderate
Fluoxetine vs citalopram Failure to respond (reduction ≥ 50% on HDRS) · patients with depression Fluoxetine versus other types of pharmacotherapy for depression (2013) · Cochrane	OR 0.6 [0.2, 1.79]	1 study · 59 participants	Very low
Fluoxetine vs citalopram Endpoint score (HDRS or MADRS) · patients with depression Fluoxetine versus other types of pharmacotherapy for depression (2013) · Cochrane	no estimate extracted	3 studies · 661 participants	Moderate
Fluoxetine vs citalopram Failure to complete ‐ total ‐ · patients with depression Fluoxetine versus other types of pharmacotherapy for depression (2013) · Cochrane	OR 0.87 [0.6, 1.27]	3 studies · 732 participants	Moderate
Fluoxetine vs citalopram Failure to complete ‐ inefficacy ‐ · patients with depression Fluoxetine versus other types of pharmacotherapy for depression (2013) · Cochrane	OR 0.87 [0.48, 1.56]	3 studies · 732 participants	Moderate
Fluoxetine vs citalopram Failure to complete ‐ side effects ‐ · patients with depression Fluoxetine versus other types of pharmacotherapy for depression (2013) · Cochrane	OR 0.64 [0.34, 1.2]	3 studies · 732 participants	Moderate
Fluoxetine vs Crocus sativus Failure to respond (reduction ≥ 50% on HDRS) · patients with depression Fluoxetine versus other types of pharmacotherapy for depression (2013) · Cochrane	OR 0.53 [0.11, 2.6]	1 study · 40 participants	Very low
Fluoxetine vs Crocus sativus Endpoint score (HDRS or MADRS) · patients with depression Fluoxetine versus other types of pharmacotherapy for depression (2013) · Cochrane	no estimate extracted	0 studies · 0 participants	Ungraded
Fluoxetine vs Crocus sativus Failure to complete ‐ total ‐ · patients with depression Fluoxetine versus other types of pharmacotherapy for depression (2013) · Cochrane	OR 1 [0.06, 17.18]	1 study · 40 participants	Very low
Fluoxetine vs Crocus sativus Failure to complete ‐ inefficacy ‐ · patients with depression Fluoxetine versus other types of pharmacotherapy for depression (2013) · Cochrane	no estimate extracted	0 studies · 0 participants	Ungraded
Fluoxetine vs TCAs Failure to complete ‐ side effects ‐ · patients with depression Fluoxetine versus other types of pharmacotherapy for depression (2013) · Cochrane	OR 0.55 [0.4, 0.75]	40 studies · 3647 participants	Moderate
Fluoxetine vs Crocus sativus Failure to complete ‐ side effects ‐ · patients with depression Fluoxetine versus other types of pharmacotherapy for depression (2013) · Cochrane	no estimate extracted	0 studies · 0 participants	Ungraded
Fluoxetine vs duloxetine Failure to respond (reduction ≥ 50% on HDRS) · patients with depression Fluoxetine versus other types of pharmacotherapy for depression (2013) · Cochrane	OR 1.41 [0.61, 3.25]	1 study · 103 participants	Low
Fluoxetine vs duloxetine Endpoint score (HDRS or MADRS) · patients with depression Fluoxetine versus other types of pharmacotherapy for depression (2013) · Cochrane	no estimate extracted	0 studies · 0 participants	Ungraded
Fluoxetine vs duloxetine Failure to complete ‐ total ‐ · patients with depression Fluoxetine versus other types of pharmacotherapy for depression (2013) · Cochrane	OR 0.9 [0.53, 1.52]	2 studies · 532 participants	Moderate
Fluoxetine vs duloxetine Failure to complete ‐ inefficacy ‐ · patients with depression Fluoxetine versus other types of pharmacotherapy for depression (2013) · Cochrane	OR 3.33 [0.93, 12.11]	2 studies · 432 participants	Moderate
Fluoxetine vs duloxetine Failure to complete ‐ side effects ‐ · patients with depression Fluoxetine versus other types of pharmacotherapy for depression (2013) · Cochrane	OR 0.28 [0.07, 1.23]	2 studies · 532 participants	Moderate
Fluoxetine vs escitalopram Failure to respond (reduction ≥ 50% on HDRS) · patients with depression Fluoxetine versus other types of pharmacotherapy for depression (2013) · Cochrane	OR 1.02 [0.56, 1.85]	1 study · 240 participants	Low
Fluoxetine vs escitalopram Endpoint score (HDRS or MADRS) · patients with depression Fluoxetine versus other types of pharmacotherapy for depression (2013) · Cochrane	no estimate extracted	1 study · 231 participants	Low
Fluoxetine vs escitalopram Failure to complete ‐ total ‐ · patients with depression Fluoxetine versus other types of pharmacotherapy for depression (2013) · Cochrane	OR 1.53 [1, 2.37]	2 studies · 578 participants	Moderate
Fluoxetine vs escitalopram Failure to complete ‐ inefficacy ‐ · patients with depression Fluoxetine versus other types of pharmacotherapy for depression (2013) · Cochrane	OR 1.74 [0.46, 6.53]	2 studies · 578 participants	Moderate
Fluoxetine vs TCAs Failure to complete ‐ inefficacy ‐ · patients with depression Fluoxetine versus other types of pharmacotherapy for depression (2013) · Cochrane	OR 1.29 [0.96, 1.72]	33 studies · 2911 participants	Moderate