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Evidence found and GRADE certainty

2,890 questions · 3,917 findings · 272 reviews · All outcomes

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No studies found 429 · 11%GRADE not reported 2,657 · 67.8%Very low 512 · 13.1%Low 219 · 5.6%Moderate 80 · 2%High 20 · 0.5%

Intervention not reported

Composite: Preference for replacement over repair - Scenario 7: non-stable (mobile) restoration

The intervention led to higher composite: Preference for replacement over repair - Scenario 7:…; GRADE not reported.

1 finding from 1 review

Intervention not reported

Composite: Preference for replacement over repair - Scenario 2: loss of dental hard substance adjacent to the restoration

The intervention showed no clear difference in composite: Preference for replacement over repair - Scenario 2: loss…; GRADE not reported.

1 finding from 1 review

Postbiotics from Lactobacillus spp. (cell-free supernatants, biosurfactants, lipoteichoic acid, bacterial lysates) vs No prior SDF application (untreated dentin control)

Downregulation of S. mutans virulence/biofilm gene expression (gtfB, gtfC, ftf) · Cariogenic bacteria (mainly Streptococcus mutans reference strains) and oral biofilms in vitro

Postbiotics reduce expression of S. mutans biofilm/virulence genes (gtfB, gtfC, ftf) in vitro (ungraded narrative synthesis).

1 finding from 1 review
  • Postbiotics and Dental Caries: A Systematic Review. 2025 All outcomes
    Exposure 24 h to 7 days · Laboratory (in vitro)
    Postbiotics downregulated expression of S. mutans virulence and exopolysaccharide-synthesis genes (e.g., gtfB, gtfC, gtfD, ftf) in 10 in vitro studies; no pooled estimate.
    8 studies
    GRADE not reported

Intervention not reported

Composite: Preference for replacement over repair - Scenario 8: disruption of occlusal integrity

The intervention led to lower composite: Preference for replacement over repair - Scenario 8:…; GRADE not reported.

1 finding from 1 review

Intervention not reported

Composite: Preference for replacement over repair - Scenario 1: partial loss or fracture of the restoration

The intervention led to lower composite: Preference for replacement over repair - Scenario 1:…; GRADE not reported.

1 finding from 1 review

Iron deficiency anemia (IDA) vs Children without anemia (non-anemic)

Dental caries · Children or adolescents

Children with iron deficiency anemia are over three times more likely to have dental caries than non-anemic children (OR 3.64, 95% CI 2.45 to 5.40; moderate certainty).

1 finding from 1 review

Replacement of the defective restoration vs Repair of the defective restoration

Composite: Preference for replacement over repair - Scenario 2: loss of dental hard substance adjacent to the restoration · Dentists managing a defective direct resin composite restoration (posterior occlusal Class I; standardized vignette of a 30-year-old,…

For a defective composite restoration with loss of dental hard substance adjacent to the restoration, surveyed dentists most often preferred repair over replacement (pooled RR 0.75; p = 0.004); ungraded.

1 finding from 1 review