Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,310 questions · 1,358 findings · 214 reviews

No studies found 230 · 16.9%GRADE not reported 169 · 12.4%Very low 269 · 19.8%Low 277 · 20.4%Moderate 291 · 21.4%High 122 · 9%

Cataract surgery with Hydrus microstent vs cataract surgery alone

Proportion of participants who required further glaucoma surgery, including laser · people with cataracts and open angle glaucoma, many of whom had mild or moderate glaucoma, which was well‐controlled with medication

Cataract surgery with Hydrus microstent may leads to lower proportion of participants who required further glaucoma surgery,… compared with cataract surgery alone (low certainty).

1 finding from 1 review

Cataract surgery with Hydrus microstent vs cataract surgery alone

Glaucoma progression at 12 months, measured by additional visual field defects · people with cataracts and open angle glaucoma, many of whom had mild or moderate glaucoma, which was well‐controlled with medication

The review found no eligible studies for this question.

1 finding from 1 review

Cataract surgery with Hydrus microstent vs cataract surgery alone

Mean change in health‐related quality of life · people with cataracts and open angle glaucoma, many of whom had mild or moderate glaucoma, which was well‐controlled with medication

The review found no eligible studies for this question.

1 finding from 1 review

Hydrus microstent vs iStent trabecular micro‐bypass stent

Proportion of participants who were medication‐free (not using eye drops) short‐term · people with open angle glaucoma, many of whom had mild or moderate glaucoma, which was well‐controlled with medication

Hydrus microstent may leads to higher proportion of participants who were medication‐free (not using eye… compared with iStent trabecular micro‐bypass stent (low certainty).

1 finding from 1 review

Hydrus microstent vs iStent trabecular micro‐bypass stent

Mean change in unmedicated IOP (after washout) measured using Goldmann applanation tonometry short‐term · people with open angle glaucoma, many of whom had mild or moderate glaucoma, which was well‐controlled with medication
1 finding from 1 review

Intervention not reported

Placebo · patients with moderate to severe eczema

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Tezepelumab (1 RCT; 56 participants) · patients with moderate to severe eczema

The intervention showed no clear difference in tezepelumab (1 RCT; 56 participants) (low certainty).

1 finding from 1 review

Intervention not reported

Lebrikizumab (1 RCT; 156 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes lebrikizumab (1 RCT; 156 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

PF‐04965842 (1 RCT; 211 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes PF‐04965842 (1 RCT; 211 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Tralokinumab (1 RCT; 153 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes tralokinumab (1 RCT; 153 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Apremilast (1 RCT; 121 participants) · patients with moderate to severe eczema

The intervention showed no clear difference in apremilast (1 RCT; 121 participants) (low certainty).

1 finding from 1 review

Intervention not reported

Baricitinib (1 RCT; 75 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes baricitinib (1 RCT; 75 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Placebo · patients with moderate to severe eczema

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Total studies: 6 RCTsTotal participants: 1720 · patients with moderate to severe eczema
1 finding from 1 review

Intervention not reported

Dupilumab (3 RCTs; 1082 participants) · patients with moderate to severe eczema

The intervention showed no clear difference in dupilumab (3 RCTs; 1082 participants) (low certainty).

1 finding from 1 review

Intervention not reported

Methotrexate (1 RCT; 50 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes methotrexate (1 RCT; 50 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Placebo · patients with moderate to severe eczema

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Fezakinumab (1 RCT; 40 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes fezakinumab (1 RCT; 40 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

QGE031 (1 RCT; 10 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes QGE031 (1 RCT; 10 participants) (very low certainty).

1 finding from 1 review