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Evidence found and GRADE certainty

1,078 questions · 1,098 findings · 33 reviews · Skin

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No studies found 396 · 36.1%GRADE not reported 89 · 8.1%Very low 181 · 16.5%Low 183 · 16.7%Moderate 196 · 17.9%High 53 · 4.8%

Clindamycin phosphate 1.2% + tretinoin 0.025% gel vs placebo

Proportion of participants with adverse event · Participants with rosacea

Clindamycin phosphate 1.2% + tretinoin 0.025% gel probably leads to higher proportion of participants with adverse event compared with placebo (moderate certainty).

1 finding from 1 review

Clindamycin phosphate 1.2% + tretinoin 0.025% gel vs placebo

Assessment of erythema or telangiectasia · Participants with rosacea

Clindamycin phosphate 1.2% + tretinoin 0.025% gel showed no clear difference in assessment of erythema or telangiectasia compared with placebo (moderate certainty).

1 finding from 1 review

Tetracycline vs placebo

HRQOL ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Tetracycline vs placebo

Participant‐assessed improvement in rosacea severity · Participants with rosacea

Tetracycline showed no clear difference in participant‐assessed improvement in rosacea severity compared with placebo (moderate certainty).

1 finding from 1 review

Tetracycline vs placebo

Proportion of participants with adverse event · Participants with rosacea

Tetracycline showed no clear difference in proportion of participants with adverse event compared with placebo (moderate certainty).

1 finding from 1 review

Tetracycline vs placebo

Physician‐assessed improvement in rosacea severity · Participants with rosacea
1 finding from 1 review