Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,138 questions · 1,154 findings · 139 reviews · Headline outcomes only

No studies found 184 · 15.9%GRADE not reported 183 · 15.9%Very low 273 · 23.7%Low 296 · 25.6%Moderate 171 · 14.8%High 47 · 4.1%

CLOZAPINE + RISPERIDONE vs CLOZAPINE + ZIPRASIDONE (Kuwilsky 2010)

Quality of life/satisfaction with care for either recipients of care or carers: significant change in quality of life/satisfaction · people with treatment‐resistant schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

CLOZAPINE + ZIPRASIDONE vs CLOZAPINE + QUETIAPINE (Wen 2015)

Clinical response: no clinically significant response in mental state: ≥ 50% reduction in PANSS total score Medium term (12 weeks) · people with treatment‐resistant schizophrenia

CLOZAPINE + ZIPRASIDONE may leads to lower clinical response: no clinically significant response in mental… compared with CLOZAPINE + QUETIAPINE (Wen 2015) (low certainty).

1 finding from 1 review

CLOZAPINE + ZIPRASIDONE vs CLOZAPINE + QUETIAPINE (Wen 2015)

Quality of life/satisfaction with care for either recipients of care or carers: significant change in quality of life/satisfaction · people with treatment‐resistant schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

CLOZAPINE + ARIPIPRAZOLE vs CLOZAPINE + HALOPERIDOL (Cipriani 2013)

Quality of life/satisfaction with care for either recipients of care or carers: significant change in quality of life/satisfaction · people with treatment‐resistant schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Pain freedom at 2 h · acute treatment of migraine in children

The intervention led to higher pain freedom at 2 h; GRADE not reported.

1 finding from 1 review

Intervention not reported

Pain freedom at 2 h · acute treatment of migraine in children

The intervention probably leads to higher pain freedom at 2 h (moderate certainty).

1 finding from 1 review

Intervention not reported

Pain freedom at 2 h · acute treatment of migraine in adolescents

The intervention probably leads to higher pain freedom at 2 h (moderate certainty).

1 finding from 1 review