Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

864 questions · 895 findings · 140 reviews · Headline outcomes only

No studies found 202 · 22.6%GRADE not reported 53 · 5.9%Very low 227 · 25.4%Low 254 · 28.4%Moderate 131 · 14.6%High 28 · 3.1%

Auto‐CPAP vs fixed CPAP

Number of participants using machine for 4 or more hours per night · adults with a diagnosis of OSA

Auto‐CPAP showed no clear difference in number of participants using machine for 4 or more hours per night compared with fixed CPAP (low certainty).

1 finding from 1 review

CPAP with expiratory pressure relief vs fixed CPAP

Withdrawals (parallel group trials/first arm cross‐over trials) · adults with a diagnosis of sleep apnoea

CPAP with expiratory pressure relief showed no clear difference in withdrawals (parallel group trials/first arm cross‐over trials) compared with fixed CPAP (low certainty).

1 finding from 1 review

Heated humidification + fixed CPAP vs fixed CPAP

Withdrawals (parallel group trials/first arm cross‐over trials) · adults with a diagnosis of sleep apnoea

It is very uncertain whether heated humidification + fixed CPAP changes withdrawals (parallel group trials/first arm cross‐over trials) compared with fixed CPAP alone (very low certainty).

1 finding from 1 review

Heated humidification + fixed CPAP vs fixed CPAP

Adverse events (machine tolerability outcomes) assessed as number of participants experiencing a blocked nose · adults with a diagnosis of sleep apnoea

Heated humidification + fixed CPAP may leads to lower adverse events (machine tolerability outcomes) assessed as number of… compared with fixed CPAP alone (low certainty).

1 finding from 1 review

Auto‐CPAP vs fixed CPAP

Withdrawals (parallel group trials/first arm cross‐over trials) · adults with a diagnosis of OSA

Auto‐CPAP showed no clear difference in withdrawals (parallel group trials/first arm cross‐over trials) Median compared with fixed CPAP (moderate certainty).

1 finding from 1 review