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Search review questions
Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
970 questions in 77 reviews · Epilepsy
current versionsNo studies 190 · 19.6%Ungraded 42 · 4.3%Very low 135 · 13.9%Low 289 · 29.8%Moderate 242 · 24.9%High 72 · 7.4%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Continuous phenobarbital vs placebo or no treatment Recurrent seizure at 24 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | RR 0.69 [0.53, 0.89] | 3 studies · 533 participants | Moderate |
Continuous phenobarbital vs placebo or no treatment Recurrent seizure at 36 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Continuous phenobarbital vs placebo or no treatment Recurrent seizure at 48 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Continuous phenobarbital vs placebo or no treatment Recurrent seizure at 60 months or greater · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | RR 1.5 [0.61, 3.69] | 1 study · 60 participants | Very low |
Intermittent phenobarbital vs placebo or no treatment Recurrent seizure at 6 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | RR 1.37 [0.67, 2.81] | 2 studies · 281 participants | Very low |
Intermittent phenobarbital vs placebo or no treatment Recurrent seizure at 12 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | RR 1.01 [0.65, 1.59] | 2 studies · 281 participants | Moderate |
Intermittent phenobarbital vs placebo or no treatment Recurrent seizure at 18 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Intermittent phenobarbital vs placebo or no treatment Recurrent seizure at 24 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | RR 0.85 [0.57, 1.28] | 1 study · 249 participants | Low |
Intermittent phenobarbital vs placebo or no treatment Recurrent seizure at 36 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Intermittent oral or rectal diazepam vs placebo or no treatment Recurrent seizure at 12 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | RR 0.69 [0.56, 0.84] | 8 studies · 1416 participants | Moderate |
Intermittent phenobarbital vs placebo or no treatment Recurrent seizure at 48 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Intermittent phenobarbital vs placebo or no treatment Recurrent seizure at 60 months or greater · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | RR 0.83 [0.28, 2.44] | 1 study · 60 participants | Very low |
Continuous oral phenytoin vs placebo Recurrent seizure at 6 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Continuous oral phenytoin vs placebo Recurrent seizure at 12 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | RR 0.98 [0.55, 1.73] | 1 study · 90 participants | Low |
Continuous oral phenytoin vs placebo Recurrent seizure at 18 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Continuous oral phenytoin vs placebo Recurrent seizure at 24 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Continuous oral phenytoin vs placebo Recurrent seizure at 36 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Continuous oral phenytoin vs placebo Recurrent seizure at 48 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Continuous oral phenytoin vs placebo Recurrent seizure at 60 months or greater · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Continuous oral valproate vs placebo or no treatment Recurrent seizure at 6 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | RR 1.2 [0.55, 2.62] | 2 studies · 156 participants | Low |
Intermittent oral or rectal diazepam vs placebo or no treatment Recurrent seizure at 18 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | RR 0.37 [0.23, 0.6] | 1 study · 289 participants | Low |
Continuous oral valproate vs placebo or no treatment Recurrent seizure at 12 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | RR 0.82 [0.52, 1.29] | 4 studies · 255 participants | Low |
Continuous oral valproate vs placebo or no treatment Recurrent seizure at 18 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | RR 0.13 [0.02, 0.96] | 1 study · 48 participants | Very low |
Continuous oral valproate vs placebo or no treatment Recurrent seizure at 24 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | RR 1.26 [0.73, 2.18] | 2 studies · 156 participants | Low |
Continuous oral valproate vs placebo or no treatment Recurrent seizure at 36 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Continuous oral valproate vs placebo or no treatment Recurrent seizure at 48 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Continuous oral valproate vs placebo or no treatment Recurrent seizure at 60 months or greater · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Continuous oral pyridoxine vs placebo Recurrent seizure at 6 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | RR 0.47 [0.15, 1.48] | 1 study · 107 participants | Low |
Continuous oral pyridoxine vs placebo Recurrent seizure at 12 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | RR 0.66 [0.27, 1.61] | 1 study · 107 participants | Low |
Continuous oral pyridoxine vs placebo Recurrent seizure at 18 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Continuous oral pyridoxine vs placebo Recurrent seizure at 24 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Intermittent oral or rectal diazepam vs placebo or no treatment Recurrent seizure at 24 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | RR 0.73 [0.56, 0.95] | 4 studies · 739 participants | High |
Continuous oral pyridoxine vs placebo Recurrent seizure at 36 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Continuous oral pyridoxine vs placebo Recurrent seizure at 48 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Continuous oral pyridoxine vs placebo Recurrent seizure at 60 months or greater · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Intermittent oral ibuprofen vs placebo Recurrent seizure at 6 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | RR 1.11 [0.69, 1.81] | 1 study · 230 participants | High |
Intermittent oral ibuprofen vs placebo Recurrent seizure at 12 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | RR 0.95 [0.63, 1.43] | 1 study · 230 participants | High |
Intermittent oral ibuprofen vs placebo Recurrent seizure at 18 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Intermittent oral ibuprofen vs placebo Recurrent seizure at 24 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | RR 0.84 [0.59, 1.19] | 1 study · 230 participants | High |
Intermittent oral ibuprofen vs placebo Recurrent seizure at 36 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Intermittent oral ibuprofen vs placebo Recurrent seizure at 48 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Intermittent oral ibuprofen vs placebo Recurrent seizure at 60 months or greater · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Intermittent oral or rectal diazepam vs placebo or no treatment Recurrent seizure at 36 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | RR 0.58 [0.4, 0.85] | 1 study · 139 participants | Low |
Intermittent oral clobazam vs placebo Recurrent seizure at 6 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | RR 0.36 [0.2, 0.64] | 1 study · 60 participants | Low |
Intermittent oral clobazam vs placebo Recurrent seizure at 12 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Intermittent oral clobazam vs placebo Recurrent seizure at 18 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Intermittent oral clobazam vs placebo Recurrent seizure at 24 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Intermittent oral clobazam vs placebo Recurrent seizure at 36 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Intermittent oral clobazam vs placebo Recurrent seizure at 48 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Intermittent oral clobazam vs placebo Recurrent seizure at 60 months or greater · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |