Intervention not reported
Total studies: 38 Total participants: 12,985 · people with chronic pain Interventions: duloxetine (all doses combined), milnacipran (all doses combined), mirtazapine (all doses…
1 finding from 1 review
no estimate extracted
38 participants
GRADE not reported
Intervention not reported
Mirtazapine RCTs: 1 Participants: 406 · people with chronic pain Interventions: duloxetine (all doses combined), milnacipran (all doses combined), mirtazapine (all doses…
1 finding from 1 review
no estimate extracted
1 participants
Low
Intervention not reported
Duloxetine RCTs: 26 Participants: 7952 · people with chronic pain Interventions: duloxetine (all doses combined), milnacipran (all doses combined), mirtazapine (all doses…
1 finding from 1 review
no estimate extracted
26 participants
Moderate
Intervention not reported
Duloxetine standard dose RCTs: 16 Participants: 4490 · people with chronic pain Interventions: desvenlafaxine high dose (≥ 50 mg); duloxetine low dose (< 60 mg), standard dose (60 mg), and high…
1 finding from 1 review
no estimate extracted
16 participants
Moderate
Intervention not reported
Milnacipran RCTs: 5 Participants: 3109 · people with chronic pain Interventions: duloxetine (all doses combined), milnacipran (all doses combined), mirtazapine (all doses…
1 finding from 1 review
no estimate extracted
5 participants
Moderate
Intervention not reported
Duloxetine high dose RCTs: 14 Participants: 3692 · people with chronic pain Interventions: desvenlafaxine high dose (≥ 50 mg); duloxetine low dose (< 60 mg), standard dose (60 mg), and high…
1 finding from 1 review
no estimate extracted
14 participants
Moderate
Intervention not reported
Milnacipran high dose RCTs: 1 Participants: 384 · people with chronic pain Interventions: desvenlafaxine high dose (≥ 50 mg); duloxetine low dose (< 60 mg), standard dose (60 mg), and high…
1 finding from 1 review
no estimate extracted
1 participants
Very low
Intervention not reported
Esreboxetine standard dose RCTs: 1 Participants: 828 · people with chronic pain Interventions: desvenlafaxine high dose (≥ 50 mg); duloxetine low dose (< 60 mg), standard dose (60 mg), and high…
1 finding from 1 review
no estimate extracted
1 participants
Low
Intervention not reported
Milnacipran standard dose RCTs: 2 Participants: 1298 · people with chronic pain Interventions: desvenlafaxine high dose (≥ 50 mg); duloxetine low dose (< 60 mg), standard dose (60 mg), and high…
1 finding from 1 review
no estimate extracted
2 participants
Low
Intervention not reported
Mirtazapine standard dose RCTs: 1 Participants: 422 · people with chronic pain Interventions: desvenlafaxine high dose (≥ 50 mg); duloxetine low dose (< 60 mg), standard dose (60 mg), and high…
1 finding from 1 review
no estimate extracted
1 participants
Low
Intervention not reported
Duloxetine low dose RCTs: 6 Participants: 1116 · people with chronic pain Interventions: desvenlafaxine high dose (≥ 50 mg); duloxetine low dose (< 60 mg), standard dose (60 mg), and high…
1 finding from 1 review
no estimate extracted
6 participants
Moderate
Intervention not reported
Esreboxetine high dose RCTs: 1 Participants: 555 · people with chronic pain Interventions: desvenlafaxine high dose (≥ 50 mg); duloxetine low dose (< 60 mg), standard dose (60 mg), and high…
1 finding from 1 review
no estimate extracted
1 participants
Very low
Diagnosis of PTSD after treatment · various
It is very uncertain whether any early psychological intervention changes PTSD diagnosis: post‐treatment compared with waiting list/usual care (very low certainty).
1 finding from 1 review
Depressive symptoms · various
1 finding from 1 review
Anxiety · various
1 finding from 1 review
General functioning ‐ not measured · various
1 finding from 1 review
PTSD diagnosis · various
Any early psychological intervention may leads to lower PTSD diagnosis: 3–6 months compared with waiting list/usual care (low certainty).
2 findings from 1 review
Dropout · various
Any early psychological intervention showed no clear difference in dropouts from treatment compared with waiting list/usual care (low certainty).
1 finding from 1 review
Severity of PTSD symptoms · various
1 finding from 1 review
Depressive symptoms · various
1 finding from 1 review