Findings

What do systematic reviews say?

189 questions · 190 findings · 12 reviews · Eyes and Vision

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No studies found 57 · 30%GRADE not reported 4 · 2.1%Very low 53 · 27.9%Low 33 · 17.4%Moderate 28 · 14.7%High 15 · 7.9%

Rituximab vs intravenous methylprednisolone

Quality of life improvement by at least 6 points · thyroid‐associated ophthalmopathy

1 finding from 1 review

Rituximab for thyroid‐associated ophthalmopathy 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 27 participants
Very low

Rituximab vs intravenous methylprednisolone

Adverse events · thyroid‐associated ophthalmopathy

Summary of findings table ‐ Rituximab showed no clear difference in adverse events compared with intravenous methylprednisolone (low certainty).

1 finding from 1 review

Rituximab for thyroid‐associated ophthalmopathy 2022 · Cochrane Headline outcomes only
RR 1.39 [0.9, 2.13]
1 study · 31 participants
Low

Rituximab vs placebo

CAS improvement (decrease) by 2 or more points · thyroid‐associated ophthalmopathy

It is very uncertain whether summary of findings table ‐ Rituximab changes CAS improvement (decrease) by 2 or more points compared with placebo (very low certainty).

1 finding from 1 review

Rituximab for thyroid‐associated ophthalmopathy 2022 · Cochrane Headline outcomes only
RR 1.23 [0.34, 4.4]
1 study · 25 participants
Very low

Rituximab vs placebo

NOSPECS improvement (decrease) by 2 classes or more · thyroid‐associated ophthalmopathy

It is very uncertain whether summary of findings table ‐ Rituximab changes NOSPECS improvement (decrease) by 2 classes or more compared with placebo (very low certainty).

1 finding from 1 review

Rituximab for thyroid‐associated ophthalmopathy 2022 · Cochrane Headline outcomes only
RR 0.92 [0.15, 5.56]
1 study · 25 participants
Very low

Summary of findings: intracanalicular vs silicone punctal plugs

Symptomatic improvement · adults with dry eye syndrome

1 finding from 1 review

Punctal occlusion for dry eye syndrome 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Summary of findings: intracanalicular vs silicone punctal plugs

Ocular surface staining · adults with dry eye syndrome

1 finding from 1 review

Punctal occlusion for dry eye syndrome 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Summary of findings: intracanalicular vs silicone punctal plugs

Aqueous tear production · adults with dry eye syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Punctal occlusion for dry eye syndrome 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: intracanalicular vs silicone punctal plugs

Tear film stability · adults with dry eye syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Punctal occlusion for dry eye syndrome 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: intracanalicular vs silicone punctal plugs

Artificial tear use · adults with dry eye syndrome

1 finding from 1 review

Punctal occlusion for dry eye syndrome 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Summary of findings: intracanalicular vs silicone punctal plugs

Adverse events · adults with dry eye syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Punctal occlusion for dry eye syndrome 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: autologous serum vs artificial tears

Participant‐reported symptoms Range of scale: 0‐100, where a higher score is worse · people with dry eye

1 finding from 1 review

Autologous serum eye drops for dry eye 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Low

Summary of findings: autologous serum vs Normal saline

Fluorescein staining Range of scale: 0‐9, where a higher score is worse · people with dry eye

The review found no eligible studies for this question.

1 finding from 1 review

Autologous serum eye drops for dry eye 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: autologous serum vs Normal saline

Rose Bengal staining Range of scale: 0‐9, where a higher score is worse · people with dry eye

1 finding from 1 review

Autologous serum eye drops for dry eye 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 35 participants
Very low

Summary of findings: autologous serum vs Normal saline

Tear film stability · people with dry eye

The review found no eligible studies for this question.

1 finding from 1 review

Autologous serum eye drops for dry eye 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: autologous serum vs Normal saline

Schirmer’s test Score < 4 mm indicates severe dry eye · people with dry eye

The review found no eligible studies for this question.

1 finding from 1 review

Autologous serum eye drops for dry eye 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: autologous serum vs Normal saline

Adverse events · people with dry eye

The review found no eligible studies for this question.

1 finding from 1 review

Autologous serum eye drops for dry eye 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: autologous serum vs artificial tears

Tear hyperosmolarity · people with dry eye

The review found no eligible studies for this question.

1 finding from 1 review

Autologous serum eye drops for dry eye 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: autologous serum vs artificial tears

Fluorescein staining Range of scale: 0‐9, where a higher score is worse · people with dry eye

1 finding from 1 review

Autologous serum eye drops for dry eye 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Low

Summary of findings: autologous serum vs artificial tears

Rose Bengal staining Range of scale: 0‐9, where a higher score is worse · people with dry eye

1 finding from 1 review

Autologous serum eye drops for dry eye 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Low

Summary of findings: autologous serum vs artificial tears

Tear film stability · people with dry eye

1 finding from 1 review

Autologous serum eye drops for dry eye 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Low