Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

89 questions · 93 findings · 8 reviews · Haematology

No studies found 18 · 19.4%GRADE not reported 17 · 18.3%Very low 14 · 15.1%Low 25 · 26.9%Moderate 17 · 18.3%High 2 · 2.2%

Prophylactic platelet transfusions with low‐dose schedule vs prophylactic platelet transfusions with standard‐dose schedule

Mortality from all causes up to 30 days from study entry · People with a haematological disorder

Prophylactic platelet transfusions with low‐dose schedule showed no clear difference in mortality from all causes up to 30 days from study entry compared with prophylactic platelet transfusions with standard‐dose schedule (low certainty).

1 finding from 1 review

Prophylactic platelet transfusions with low‐dose schedule vs high‐dose schedule

Number of participants with at least 1 clinically significant bleeding event up to 30 days from study entry · People with a haematological disorder

Prophylactic platelet transfusions with low‐dose schedule showed no clear difference in number of participants with at least 1 clinically significant… compared with high‐dose schedule (moderate certainty).

1 finding from 1 review

Intervention not reported

Treatment‐related mortality ‐ overall analysis (at 3 years) · Patients with refractory/relapsed Hodgkin lymphoma

The intervention showed no clear difference in treatment‐related mortality ‐ overall analysis (at 3 years) (moderate certainty).

1 finding from 1 review

Prophylactic platelet transfusion vs non prophylactic or therapeutic platelet transfusion

Bleeding: Numbers of patients with at least one significant bleeding event · People with a haematological disorder

Prophylactic platelet transfusion showed no clear difference in bleeding: Numbers of patients with at least one significant bleeding… compared with non prophylactic or therapeutic platelet transfusion (low certainty).

1 finding from 1 review

Prophylactic platelet transfusion with one dose schedule vs prophylactic platelet transfusions with another dose schedule

Bleeding: Numbers of patients with at least one significant bleeding event · People with a haematological disorder

Prophylactic platelet transfusion with one dose schedule showed no clear difference in bleeding Number of participants with a significant bleeding event ‐… compared with prophylactic platelet transfusions with another dose schedule (high certainty).

2 findings from 1 review

Prophylactic platelet transfusion with one dose schedule vs prophylactic platelet transfusions with another dose schedule

Bleeding Number of days with significant bleeding ‐ Low dosage platelet transfusions versus standard dosage platelet transfusions · People with a haematological disorder
1 finding from 1 review

Prophylactic platelet transfusion with one dose schedule vs prophylactic platelet transfusions with another dose schedule

Bleeding: Number of days with significant bleeding ‐ High dosage platelet transfusions versus standard dosage platelet transfusions · People with a haematological disorder
1 finding from 1 review

Prophylactic platelet transfusion with one dose schedule vs prophylactic platelet transfusions with another dose schedule

Mortality: secondary to bleeding · People with a haematological disorder
2 findings from 1 review

Prophylactic platelet transfusion vs platelet‐poor plasma

Bleeding: Numbers of patients with at least one significant bleeding event · People with a haematological disorder

It is very uncertain whether prophylactic platelet transfusion changes number of participants with a significant bleeding event compared with platelet‐poor plasma (very low certainty).

1 finding from 1 review

Prophylactic platelet transfusion vs platelet‐poor plasma

Mortality: secondary to bleeding · People with a haematological disorder

It is very uncertain whether prophylactic platelet transfusion changes mortality: secondary to bleeding compared with platelet‐poor plasma (very low certainty).

1 finding from 1 review

Prophylactic platelet transfusion vs non prophylactic or therapeutic platelet transfusion

Bleeding: Number of days on which a significant bleeding event occurred3 · People with a haematological disorder

Prophylactic platelet transfusion showed no clear difference in bleeding: Number of days on which a significant bleeding event… compared with non prophylactic or therapeutic platelet transfusion (low certainty).

1 finding from 1 review

Prophylactic platelet transfusion vs non prophylactic or therapeutic platelet transfusion

Mortality: secondary to bleeding · People with a haematological disorder

Prophylactic platelet transfusion showed no clear difference in mortality: Secondary to bleeding compared with non prophylactic or therapeutic platelet transfusion (low certainty).

1 finding from 1 review