Findings

What do systematic reviews say?

82 questions · 83 findings · 9 reviews · Pregnancy and Childbirth

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No studies found 11 · 13.3%GRADE not reported 3 · 3.6%Very low 15 · 18.1%Low 31 · 37.3%Moderate 16 · 19.3%High 7 · 8.4%

Intravenous/intramuscular ergot alkaloids vs no uterotonic agents

Use of therapeutic uterotonics · women in the third stage of labour

Intravenous/intramuscular ergot alkaloids may leads to lower use of therapeutic uterotonics compared with no uterotonic agents (low certainty).

1 finding from 1 review

Prophylactic use of ergot alkaloids in the third stage of labour 2018 · Cochrane Headline outcomes only
RR 0.25 [0.1, 0.66]
2 studies · 2409 participants
Low

Intravenous/intramuscular ergot alkaloids vs no uterotonic agents

Elevation of blood pressure · women in the third stage of labour

Intravenous/intramuscular ergot alkaloids may leads to higher elevation of blood pressure compared with no uterotonic agents (low certainty).

1 finding from 1 review

Prophylactic use of ergot alkaloids in the third stage of labour 2018 · Cochrane Headline outcomes only
RR 2.6 [1.03, 6.57]
3 studies · 2559 participants
Low

Intravenous/intramuscular ergot alkaloids vs no uterotonic agents

Pain after birth requiring analgesia (not prespecified) · women in the third stage of labour

Intravenous/intramuscular ergot alkaloids probably leads to higher pain after birth requiring analgesia (not prespecified) compared with no uterotonic agents (moderate certainty).

1 finding from 1 review

Prophylactic use of ergot alkaloids in the third stage of labour 2018 · Cochrane Headline outcomes only
RR 2.53 [1.34, 4.78]
1 study · 1429 participants
Moderate

Oral ergot alkaloids vs no uterotonic agents

Mean blood loss (mL) visual estimation · women in the third stage of labour

1 finding from 1 review

Prophylactic use of ergot alkaloids in the third stage of labour 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 289 participants
Low

Oral ergot alkaloids vs no uterotonic agents

Maternal blood loss of 500 mL or greater · women in the third stage of labour

Oral ergot alkaloids showed no clear difference in estimated or measured blood loss of at least 500 mL visual estimation compared with no uterotonic agents (low certainty).

1 finding from 1 review

Prophylactic use of ergot alkaloids in the third stage of labour 2018 · Cochrane Headline outcomes only
RR 0.96 [0.72, 1.29]
1 study · 289 participants
Low

Oral ergot alkaloids vs no uterotonic agents

Severe PPH (≥ 1000 mL) · women in the third stage of labour

Oral ergot alkaloids showed no clear difference in estimated or measured blood loss of at least 1000 mL visual estimation compared with no uterotonic agents (low certainty).

1 finding from 1 review

Prophylactic use of ergot alkaloids in the third stage of labour 2018 · Cochrane Headline outcomes only
RR 0.73 [0.36, 1.5]
1 study · 289 participants
Low

Oral ergot alkaloids vs no uterotonic agents

Haemoglobin (g/dL) · women in the third stage of labour

The review found no eligible studies for this question.

1 finding from 1 review

Prophylactic use of ergot alkaloids in the third stage of labour 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Oral ergot alkaloids vs no uterotonic agents

Use of therapeutic uterotonics · women in the third stage of labour

Oral ergot alkaloids showed no clear difference in use of therapeutic uterotonics compared with no uterotonic agents (low certainty).

1 finding from 1 review

Prophylactic use of ergot alkaloids in the third stage of labour 2018 · Cochrane Headline outcomes only
RR 0.79 [0.47, 1.34]
1 study · 289 participants
Low

Ergot alkaloids (any route of administration) vs no uterotonic agents

Maternal blood loss of 500 mL or greater · women in the third stage of labour

Ergot alkaloids (any route of administration) may leads to lower PPH (estimated or measured blood loss of at least 500 mL) visual… compared with no uterotonic agents (low certainty).

1 finding from 1 review

Prophylactic use of ergot alkaloids in the third stage of labour 2018 · Cochrane Headline outcomes only
RR 0.52 [0.28, 0.94]
5 studies · 3708 participants
Low

Oral ergot alkaloids vs no uterotonic agents

Elevation of blood pressure · women in the third stage of labour

The review found no eligible studies for this question.

1 finding from 1 review

Prophylactic use of ergot alkaloids in the third stage of labour 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Oral ergot alkaloids vs no uterotonic agents

Pain after birth requiring analgesia (not prespecified) · women in the third stage of labour

The review found no eligible studies for this question.

1 finding from 1 review

Prophylactic use of ergot alkaloids in the third stage of labour 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Ergot alkaloids (any route of administration) vs no uterotonic agents

Severe PPH (≥ 1000 mL) · women in the third stage of labour

It is very uncertain whether ergot alkaloids (any route of administration) changes severe PPH (estimated or measured blood loss of at least 1000 mL)… compared with no uterotonic agents (very low certainty).

1 finding from 1 review

Prophylactic use of ergot alkaloids in the third stage of labour 2018 · Cochrane Headline outcomes only
RR 0.32 [0.04, 2.59]
2 studies · 1718 participants
Very low

Ergot alkaloids (any route of administration) vs no uterotonic agents

Haemoglobin (g/dL) · women in the third stage of labour

1 finding from 1 review

Prophylactic use of ergot alkaloids in the third stage of labour 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 1429 participants
Moderate

Ergot alkaloids (any route of administration) vs no uterotonic agents

Use of therapeutic uterotonics · women in the third stage of labour

Ergot alkaloids (any route of administration) may leads to lower use of therapeutic uterotonics compared with no uterotonic agents (low certainty).

1 finding from 1 review

Prophylactic use of ergot alkaloids in the third stage of labour 2018 · Cochrane Headline outcomes only
RR 0.37 [0.15, 0.9]
3 studies · 2698 participants
Low

Ergot alkaloids (any route of administration) vs no uterotonic agents

Elevation of blood pressure · women in the third stage of labour

Ergot alkaloids (any route of administration) may leads to higher elevation of blood pressure compared with no uterotonic agents (low certainty).

1 finding from 1 review

Prophylactic use of ergot alkaloids in the third stage of labour 2018 · Cochrane Headline outcomes only
RR 2.6 [1.03, 6.57]
3 studies · 2559 participants
Low

Ergot alkaloids (any route of administration) vs no uterotonic agents

Pain after birth requiring analgesia (not prespecified) · women in the third stage of labour

Ergot alkaloids (any route of administration) probably leads to higher pain after birth requiring analgesia (not prespecified) compared with no uterotonic agents (moderate certainty).

1 finding from 1 review

Prophylactic use of ergot alkaloids in the third stage of labour 2018 · Cochrane Headline outcomes only
RR 2.53 [1.34, 4.78]
1 study · 1429 participants
Moderate

Intravenous/intramuscular ergot alkaloids vs no uterotonic agents

Mean blood loss (mL) visual estimation · women in the third stage of labour

1 finding from 1 review

Prophylactic use of ergot alkaloids in the third stage of labour 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 2429 participants
Moderate

Intravenous/intramuscular ergot alkaloids vs no uterotonic agents

Maternal blood loss of 500 mL or greater · women in the third stage of labour

Intravenous/intramuscular ergot alkaloids may leads to lower estimated or measured blood loss of at least 500 mL visual estimation compared with no uterotonic agents (low certainty).

1 finding from 1 review

Prophylactic use of ergot alkaloids in the third stage of labour 2018 · Cochrane Headline outcomes only
RR 0.41 [0.22, 0.75]
4 studies · 3419 participants
Low

Oral betamimetic vs placebo

Preterm labour · women with a twin pregnancy

Oral betamimetic may leads to lower preterm labour compared with placebo (low certainty).

1 finding from 1 review

Prophylactic oral betamimetics for reducing preterm birth in women with a twin pregnancy 2015 · Cochrane Headline outcomes only
RR 0.37 [0.17, 0.78]
2 studies · 194 participants
Low

Oral betamimetic vs placebo

Prelabour rupture of membranes · women with a twin pregnancy

Oral betamimetic showed no clear difference in prelabour rupture of membranes compared with placebo (low certainty).

1 finding from 1 review

Prophylactic oral betamimetics for reducing preterm birth in women with a twin pregnancy 2015 · Cochrane Headline outcomes only
RR 1.42 [0.42, 4.82]
1 study · 144 participants
Low