Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

511 questions · 561 findings · 70 reviews · Gynaecology and Fertility

No studies found 91 · 16.2%GRADE not reported 5 · 0.9%Very low 140 · 25%Low 219 · 39%Moderate 98 · 17.5%High 8 · 1.4%

Hormonal therapy vs placebo or no intervention

Effect on later sexual function · Postmenopausal women
5 findings from 1 review
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GnRHa treatment vs placebo

Relief of overall pain ‐ reported as pelvic tenderness ‐ 6 months · women with endometriosis

GnRHas may leads to higher relief of overall pain ‐ reported as pelvic tenderness scores‐ 3… compared with placebo (low certainty).

1 finding from 1 review

GnRHa treatment vs placebo

Relief of overall pain ‐ reported as pelvic induration ‐ 6 months · women with endometriosis

GnRHas showed no clear difference in relief of overall pain ‐ reported as pelvic induration scores ‐ 3… compared with placebo (low certainty).

1 finding from 1 review

Any glucocorticoid vs no glucocorticoids or placebo

Ectopic pregnancy rate per couple · assisted reproduction technology cycles

It is very uncertain whether glucocorticoids changes incidence of ectopic pregnancies per couple compared with no glucocorticoids or placebo (very low certainty).

1 finding from 1 review

Any glucocorticoid vs no glucocorticoids or placebo

Incidence of OHSS per couple (mild‐severe) · assisted reproduction technology cycles

It is very uncertain whether glucocorticoids changes incidence of OHSS per couple (mild–severe) compared with no glucocorticoids or placebo (very low certainty).

1 finding from 1 review

Any glucocorticoid vs no glucocorticoids or placebo

Clinical pregnancy rate · assisted reproduction technology cycles

Glucocorticoids showed no clear difference in clinical pregnancy rate per couple –pregnancy rate per couple… compared with no glucocorticoids or placebo (low certainty).

4 findings from 1 review
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Any glucocorticoid vs no glucocorticoids or placebo

Clinical pregnancy rate per couple – subgroup IVF · assisted reproduction technology cycles

It is very uncertain whether glucocorticoids changes clinical pregnancy rate per couple – subgroup IVF compared with no glucocorticoids or placebo (very low certainty).

1 finding from 1 review

Any glucocorticoid vs no glucocorticoids or placebo

Clinical pregnancy rate per couple – subgroup ICSI · assisted reproduction technology cycles

It is very uncertain whether glucocorticoids changes clinical pregnancy rate per couple – subgroup ICSI compared with no glucocorticoids or placebo (very low certainty).

1 finding from 1 review

Antioxidants vs placebo or no treatment

Live birth rate per couple · patients with male subfertility

It is very uncertain whether antioxidants changes live birth rate per couple randomised compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Antioxidants vs placebo or no treatment

Clinical pregnancy rate · patients with male subfertility

Antioxidants may leads to higher clinical pregnancy rate per couple randomised compared with placebo or no treatment (low certainty).

1 finding from 1 review

Antioxidants vs placebo or no treatment

Adverse events ‐ Miscarriage · patients with male subfertility

It is very uncertain whether antioxidants changes adverse events ‐ Miscarriage compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Antioxidants vs placebo or no treatment

Gastrointestinal adverse events · patients with male subfertility

Antioxidants may leads to higher adverse events ‐ Gastrointestinal compared with placebo or no treatment (low certainty).

1 finding from 1 review