All‐cause mortality (30 days post‐surgery) · people undergoing definitive fixation of hip, pelvic and long bone fractures
It is very uncertain whether topical tranexamic acid changes all‐cause mortality (30 days post‐surgery) compared with placebo (very low certainty).
1 finding from 1 review
Depression at endpoint · Post‐TBI Depression
It is very uncertain whether CBT changes depression scales (BDI‐II, HAM‐D and HADS); higher score means more… compared with wait‐list control (very low certainty).
1 finding from 1 review
Depressive symptoms · Post‐TBI Depression
It is very uncertain whether CBT changes beck Depression Inventory (BDI); higher score means more depressed compared with supportive Psychotherapy (very low certainty).
1 finding from 1 review
Depression rating scale score · Post‐TBI Depression
It is very uncertain whether repetitive transcranial magnetic stimulation (rTMS) changes hamilton Rating Scale for Depression (HAM‐D); higher score means… compared with rTMS plus Tricyclic Anti‐depressant (very low certainty).
1 finding from 1 review
Beck Depression Inventory (BDI); higher score means more depression · Post‐TBI Depression
Supervised exercised showed no clear difference in beck Depression Inventory (BDI); higher score means more depression compared with exercise (low certainty).
1 finding from 1 review
Febrile reactions (fever with or without chills, chills with or without rigors) ‐ Intention‐to treat analysis · patients with requirement of prophylaxis to avoid allergic and febrile non‐haemolytic transfusion reactions
Acetaminophen plus Diphenhydramine showed no clear difference in febrile reactions (fever with or without chills, chills with or… compared with placebo (low certainty).
1 finding from 1 review
Adverse events · patients with requirement of prophylaxis to avoid allergic and febrile non‐haemolytic transfusion reactions
Acetaminophen plus Diphenhydrammine led to lower adverse events compared with placebo (Unit of randomisation: transfusion); GRADE not reported.
1 finding from 1 review
Anaphylatic reactions ‐ not reported · patients with requirement of prophylaxis to avoid allergic and febrile non‐haemolytic transfusion reactions
Acetaminophen plus Diphenhydramine led to lower anaphylatic reactions ‐ not reported compared with placebo; GRADE not reported.
1 finding from 1 review
Death ‐ not reported · patients with requirement of prophylaxis to avoid allergic and febrile non‐haemolytic transfusion reactions
Acetaminophen plus Diphenhydramine led to lower death ‐ not reported compared with placebo; GRADE not reported.
1 finding from 1 review
Adverse events · patients with requirement of prophylaxis to avoid allergic and febrile non‐haemolytic transfusion reactions
Acetaminophen plus Diphenhydramine led to lower adverse events compared with placebo; GRADE not reported.
1 finding from 1 review
Allergic reactions (urticaria with or without pruritus) ‐ Intention‐to treat analysis · patients with requirement of prophylaxis to avoid allergic and febrile non‐haemolytic transfusion reactions
It is very uncertain whether acetaminophen plus Diphenhydramine changes allergic reactions (urticaria with or without pruritus) ‐… compared with placebo (very low certainty).
1 finding from 1 review
Fever · patients with requirement of prophylaxis to avoid allergic and febrile non‐haemolytic transfusion reactions
Acetaminophen plus Diphenhydrammine showed no clear difference in fever ‐ Per protocol analysis compared with placebo (Unit of randomisation: transfusion) (low certainty).
1 finding from 1 review
Anaphylatic reactions ‐ not reported · patients with requirement of prophylaxis to avoid allergic and febrile non‐haemolytic transfusion reactions
Acetaminophen plus Diphenhydrammine led to lower anaphylatic reactions ‐ not reported compared with placebo (Unit of randomisation: transfusion); GRADE not reported.
1 finding from 1 review
Hives ‐ Per protocol analysis · patients with requirement of prophylaxis to avoid allergic and febrile non‐haemolytic transfusion reactions
Acetaminophen plus Diphenhydrammine showed no clear difference in hives ‐ Per protocol analysis compared with placebo (Unit of randomisation: transfusion) (low certainty).
1 finding from 1 review
Death ‐ not reported · patients with requirement of prophylaxis to avoid allergic and febrile non‐haemolytic transfusion reactions
Acetaminophen plus Diphenhydrammine led to lower death ‐ not reported compared with placebo (Unit of randomisation: transfusion); GRADE not reported.
1 finding from 1 review