Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

70 questions · 71 findings · 9 reviews · Headline outcomes only

No studies found 29 · 40.8%GRADE not reported 0 · 0%Very low 31 · 43.7%Low 7 · 9.9%Moderate 4 · 5.6%High 0 · 0%

Cilostazol vs pentoxifylline

Adverse event related to study medication ‐ headache (number of cases) · intermittent claudication

Cilostazol may leads to higher adverse event related to study medication ‐ headache (number of cases) compared with pentoxifylline (low certainty).

1 finding from 1 review

Prostanoids vs pentoxifylline

Adverse events (participants) · people with critical limb ischaemia

It is very uncertain whether prostanoids changes adverse events (participants) compared with pentoxifylline (very low certainty).

1 finding from 1 review

Prostanoids vs pentoxifylline

Rest‐pain relief · people with critical limb ischaemia

It is very uncertain whether prostanoids changes rest‐pain relief compared with pentoxifylline (very low certainty).

1 finding from 1 review

Prostanoids vs pentoxifylline

Ulcer healing · people with critical limb ischaemia

It is very uncertain whether prostanoids changes ulcer healing compared with pentoxifylline (very low certainty).

1 finding from 1 review

Prostanoids vs pentoxifylline

Amputation · people with critical limb ischaemia

It is very uncertain whether prostanoids changes total amputations compared with pentoxifylline (very low certainty).

1 finding from 1 review