Findings

What do systematic reviews say?

79 questions · 79 findings · 14 reviews · Heart

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No studies found 7 · 8.9%GRADE not reported 5 · 6.3%Very low 19 · 24.1%Low 25 · 31.6%Moderate 13 · 16.5%High 10 · 12.7%

Low dietary fat vs usual fat

Body fatness (represented by percentage body fat) · Adults (general population)

1 finding from 1 review

Effects of total fat intake on body fatness in adults 2020 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 2415 participants
High

Low dietary fat vs usual fat

Potential harms ‐ serum lipids, mmol/L · Adults (general population)

1 finding from 1 review

Effects of total fat intake on body fatness in adults 2020 · Cochrane Headline outcomes only
no estimate extracted
22 studies · 9812 participants
High

Low dietary fat vs usual fat

Blood pressure · Adults (general population)

1 finding from 1 review

Effects of total fat intake on body fatness in adults 2020 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 6078 participants
High

Low dietary fat vs usual fat

Potential harms ‐ quality of life (QoL) · Adults (general population)

1 finding from 1 review

Effects of total fat intake on body fatness in adults 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 40130 participants
Low

Systematic screening vs no/opportunistic screening

All‐cause mortality · general population including those at moderate to high risk of CVD, mean age between 30 and 75

Systematic screening showed no clear difference in all‐cause mortality compared with no/opportunistic screening (low certainty).

1 finding from 1 review

Systematic versus opportunistic risk assessment for the primary prevention of cardiovascular disease 2016 · Cochrane Headline outcomes only
RR 0.98 [0.93, 1.03]
3 studies · 103571 participants
Low

Systematic screening vs no/opportunistic screening

Stroke · general population including those at moderate to high risk of CVD, mean age between 30 and 75

Systematic screening showed no clear difference in stroke (total) compared with no/opportunistic screening (low certainty).

1 finding from 1 review

Systematic versus opportunistic risk assessment for the primary prevention of cardiovascular disease 2016 · Cochrane Headline outcomes only
RR 0.99 [0.9, 1.1]
2 studies · 79631 participants
Low

Systematic screening vs no/opportunistic screening

Total coronary heart disease · general population including those at moderate to high risk of CVD, mean age between 30 and 75

Systematic screening showed no clear difference in coronary heart disease (total) compared with no/opportunistic screening (low certainty).

1 finding from 1 review

Systematic versus opportunistic risk assessment for the primary prevention of cardiovascular disease 2016 · Cochrane Headline outcomes only
RR 1.01 [0.95, 1.07]
4 studies · 110168 participants
Low

Systematic screening vs no/opportunistic screening

Cholesterol mg/dL · general population including those at moderate to high risk of CVD, mean age between 30 and 75

1 finding from 1 review

Systematic versus opportunistic risk assessment for the primary prevention of cardiovascular disease 2016 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 12591 participants
Very low

Systematic screening vs no/opportunistic screening

Systolic blood pressure · general population including those at moderate to high risk of CVD, mean age between 30 and 75

1 finding from 1 review

Systematic versus opportunistic risk assessment for the primary prevention of cardiovascular disease 2016 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 12591 participants
Very low

Systematic screening vs no/opportunistic screening

Diastolic blood pressure · general population including those at moderate to high risk of CVD, mean age between 30 and 75

1 finding from 1 review

Systematic versus opportunistic risk assessment for the primary prevention of cardiovascular disease 2016 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 12591 participants
Low

Colchicine vs any control treatment

Mortality (all‐cause) · any patient population and people with high cardiovascular risk

Colchicine showed no clear difference in mortality (all‐cause) compared with any control treatment (moderate certainty).

1 finding from 1 review

Colchicine for prevention of cardiovascular events 2016 · Cochrane Headline outcomes only
RR 0.94 [0.82, 1.09]
30 studies · 4174 participants
Moderate

Colchicine vs any control treatment

Cardiovascular mortality · any patient population and people with high cardiovascular risk

Colchicine showed no clear difference in mortality (cardiovascular) compared with any control treatment (moderate certainty).

1 finding from 1 review

Colchicine for prevention of cardiovascular events 2016 · Cochrane Headline outcomes only
RR 0.34 [0.09, 1.21]
7 studies · 1132 participants
Moderate

Colchicine vs any control treatment

Myocardial infarction · any patient population and people with high cardiovascular risk

Colchicine probably leads to lower myocardial Infarction (total) compared with any control treatment (moderate certainty).

1 finding from 1 review

Colchicine for prevention of cardiovascular events 2016 · Cochrane Headline outcomes only
RR 0.2 [0.07, 0.57]
2 studies · 652 participants
Moderate

Colchicine vs any control treatment

Adverse event (total) · any patient population and people with high cardiovascular risk

It is very uncertain whether colchicine changes adverse event (total) compared with any control treatment (very low certainty).

1 finding from 1 review

Colchicine for prevention of cardiovascular events 2016 · Cochrane Headline outcomes only
RR 1.52 [0.93, 2.46]
11 studies · 1313 participants
Very low

Colchicine vs any control treatment

Gastrointestinal adverse events · any patient population and people with high cardiovascular risk

Colchicine may leads to higher adverse event (gastrointestinal) compared with any control treatment (low certainty).

1 finding from 1 review

Colchicine for prevention of cardiovascular events 2016 · Cochrane Headline outcomes only
RR 1.83 [1.03, 3.26]
11 studies · 1258 participants
Low

Colchicine vs any control treatment

Adverse event (serious) · any patient population and people with high cardiovascular risk

1 finding from 1 review

Colchicine for prevention of cardiovascular events 2016 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 472 participants
Low

Colchicine vs any control treatment

Heart failure · any patient population and people with high cardiovascular risk

Colchicine showed no clear difference in heart failure (total) compared with any control treatment (low certainty).

1 finding from 1 review

Colchicine for prevention of cardiovascular events 2016 · Cochrane Headline outcomes only
RR 0.62 [0.1, 3.88]
3 studies · 426 participants
Low

Colchicine vs any control treatment

Stroke · any patient population and people with high cardiovascular risk

Colchicine showed no clear difference in stroke (total) compared with any control treatment (low certainty).

1 finding from 1 review

Colchicine for prevention of cardiovascular events 2016 · Cochrane Headline outcomes only
OR 0.38 [0.09, 1.7]
3 studies · 874 participants
Low

Low dietary fat vs usual fat

Weight (kg) · Adults and children (general population)

1 finding from 1 review

Effects of total fat intake on body weight 2015 · Cochrane Headline outcomes only
no estimate extracted
30 studies · 53647 participants
High