Oral hydroxyurea vs placebo
Muscle strength · children and adults with SMA types II and III
1 finding from 1 review
- no estimate extracted1 study · 57 participantsModerate
Findings
What do systematic reviews say?
116 questions · 120 findings · 14 reviews · Headline outcomes only
No studies found 14 · 11.7%GRADE not reported 5 · 4.2%Very low 29 · 24.2%Low 44 · 36.7%Moderate 27 · 22.5%High 1 · 0.8%
Oral hydroxyurea vs placebo
Acquiring the ability to stand or walk · children and adults with SMA types II and III
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Oral hydroxyurea vs placebo
Change in quality of life · children and adults with SMA types II and III
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Oral hydroxyurea vs placebo
Change in pulmonary function · children and adults with SMA types II and III
1 finding from 1 review
- no estimate extracted1 study · 57 participantsLow
Epinephrine vs placebo, no treatment or any other drugs
Initiation of oral feeding (days) · patients with the management of transient tachypnea of the newborn
1 finding from 1 review
- no estimate extracted1 study · 20 participantsVery low
Intervention not reported
Proportion of patients who discontinued treatment due to adverse events (28 weeks trial period) · Patients between five and 15 years old with a diagnosis of BECTS
The intervention showed no clear difference in proportion of patients who discontinued treatment due to adverse… (low certainty).
1 finding from 1 review
- Comparison of antiepileptic drugs, no treatment, or placebo for children with benign epilepsy with centro temporal… 2014 · Cochrane Headline outcomes onlyRR 1.12 [0.36, 3.45]1 study · 112 participantsLow
Intervention not reported
Proportion of patients who discontinued treatment due to adverse events (over 6 months trial period) · Patients between three and 10 years old with a diagnosis of BECTS
1 finding from 1 review
- Comparison of antiepileptic drugs, no treatment, or placebo for children with benign epilepsy with centro temporal… 2014 · Cochrane Headline outcomes onlyno estimate extracted1 study · 66 participantsGRADE not reported
Intervention not reported
Proportion of patients who discontinued treatment due to adverse events (96 weeks trial period) · Patients with a clinical and EEG diagnosis of BECTS
It is very uncertain whether the intervention changes proportion of patients who discontinued treatment due to adverse… (very low certainty).
1 finding from 1 review
- Comparison of antiepileptic drugs, no treatment, or placebo for children with benign epilepsy with centro temporal… 2014 · Cochrane Headline outcomes onlyRR 0.72 [0.05, 10.76]1 study · 43 participantsVery low
Intervention not reported
Proportion of patients who discontinued treatment due to adverse events ( · Patients between three and 12 years old with clinical and EEG diagnosis of BECTS
The intervention showed no clear difference in proportion of patients who discontinued treatment due to adverse… (low certainty).
1 finding from 1 review
- Comparison of antiepileptic drugs, no treatment, or placebo for children with benign epilepsy with centro temporal… 2014 · Cochrane Headline outcomes onlyRR 0.86 [0.06, 12.75]1 study · 39 participantsLow
Intermittent oral or rectal diazepam vs placebo or no treatment
Recurrent seizure at 6 months · children with febrile seizures
Intermittent oral or rectal diazepam probably leads to lower recurrent seizure at 6 months compared with placebo or no treatment (moderate certainty).
1 finding from 1 review
- Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes onlyRR 0.64 [0.48, 0.85]6 studies · 1151 participantsModerate
Intermittent oral or rectal diazepam vs placebo or no treatment
Recurrent seizure at 12 months · children with febrile seizures
Intermittent oral or rectal diazepam probably leads to lower recurrent seizure at 12 months compared with placebo or no treatment (moderate certainty).
1 finding from 1 review
- Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes onlyRR 0.69 [0.56, 0.84]8 studies · 1416 participantsModerate
Intermittent oral or rectal diazepam vs placebo or no treatment
Recurrent seizure at 18 months · children with febrile seizures
Intermittent oral or rectal diazepam may leads to lower recurrent seizure at 18 months compared with placebo or no treatment (low certainty).
1 finding from 1 review
- Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes onlyRR 0.37 [0.23, 0.6]1 study · 289 participantsLow
Intermittent oral or rectal diazepam vs placebo or no treatment
Recurrent seizure at 24 months · children with febrile seizures
Intermittent oral or rectal diazepam leads to lower recurrent seizure at 24 months compared with placebo or no treatment (high certainty).
1 finding from 1 review
- Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes onlyRR 0.73 [0.56, 0.95]4 studies · 739 participantsHigh
Intermittent oral or rectal diazepam vs placebo or no treatment
Recurrent seizure at 36 months · children with febrile seizures
Intermittent oral or rectal diazepam may leads to lower recurrent seizure at 36 months compared with placebo or no treatment (low certainty).
1 finding from 1 review
- Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes onlyRR 0.58 [0.4, 0.85]1 study · 139 participantsLow
Intermittent oral or rectal diazepam vs placebo or no treatment
Recurrent seizure at 48 months · children with febrile seizures
Intermittent oral or rectal diazepam probably leads to lower recurrent seizure at 48 months compared with placebo or no treatment (moderate certainty).
1 finding from 1 review
- Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes onlyRR 0.36 [0.15, 0.89]1 study · 110 participantsModerate
Intermittent oral or rectal diazepam vs placebo or no treatment
Recurrent seizure at 60 months or greater · children with febrile seizures
It is very uncertain whether intermittent oral or rectal diazepam changes recurrent seizure at 60 months or greater compared with placebo or no treatment (very low certainty).
1 finding from 1 review
- Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes onlyRR 0.08 [0, 1.31]1 study · 60 participantsVery low
Oral valproic acid vs placebo
Change in disability score · ambulatory adults with SMA type III
1 finding from 1 review
- no estimate extracted31 participantsLow
Oral valproic acid vs placebo
Muscle strength · ambulatory adults with SMA type III
1 finding from 1 review
- no estimate extracted30 participantsLow
Oral valproic acid vs placebo
Acquiring the ability to stand or walk · ambulatory adults with SMA type III
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Oral valproic acid vs placebo
Change in quality of life · ambulatory adults with SMA type III
1 finding from 1 review
- no estimate extracted28 participantsModerate