Burning sensation (VAS 0-100) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
Antioxidants (lycopene, curcumin, Oxitard) probably leads to lower burning sensation (VAS 0-100) compared with placebo or no active treatment (moderate certainty).
3 findings from 1 review
MD -70.82 [-94.39, -47.25]
2 studies · 500 participants
Moderate
MD -30.92 [-31.57, -30.27]
1 study · 400 participants
Moderate
MD -27.60 [-36.21, -18.99]
1 study · 90 participants
Moderate
Discomfort/pain · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
The review found no eligible studies for this question.
1 finding from 1 review
Difficulty in speech (participant-reported proxy) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
Antioxidants (lycopene, curcumin, Oxitard) showed no clear difference in difficulty in speech (participant-reported proxy) compared with placebo or no active treatment; GRADE not reported.
1 finding from 1 review
Participant satisfaction · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
The review found no eligible studies for this question.
1 finding from 1 review
Improvement in range of jaw movement · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
The review found no eligible studies for this question.
1 finding from 1 review
Quality of life · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
The review found no eligible studies for this question.
1 finding from 1 review
Difficulty in swallowing (participant-reported proxy) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
Antioxidants (lycopene, curcumin, Oxitard) led to lower difficulty in swallowing (participant-reported proxy) compared with placebo or no active treatment; GRADE not reported.
1 finding from 1 review
Economic: direct costs · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
The review found no eligible studies for this question.
1 finding from 1 review
Improvement of histological features (not improved) · People with a diagnosis of oral leukoplakia
Systemic beta carotene or carotenoids (incl. lycopene) may leads to lower improvement of histological features (not improved) compared with placebo or no treatment (low certainty).
1 finding from 1 review
Malignant transformation (oral cancer development) · People with a diagnosis of oral leukoplakia
It is very uncertain whether systemic beta carotene or carotenoids (incl. lycopene) changes oral cancer development compared with placebo or no treatment (very low certainty).
1 finding from 1 review
Safety of the intervention (adverse effects) · People with a diagnosis of oral leukoplakia
1 finding from 1 review
SoF 2, Safety of the intervention at 5 to 12 months: 'Systemic beta carotene did not cause any adverse effects in 1 study supplementing 10 mg/d (Nagao), and caused adverse effects of varying severity in 9% of…
3 studies
GRADE not reported
Clinical resolution (oral lesion not completely resolved) · People with a diagnosis of oral leukoplakia
1 finding from 1 review
SoF 2, Clinical resolution (not completely resolved) at 5 to 12 months: 'The 3 studies could not be combined in meta-analysis. 2 found benefit for systemic beta carotene, and 1 did not.' No GRADE rating. Effects text…
3 studies
GRADE not reported
Canine expansion · Children and adults with a posterior crossbite, without a Class III skeletal relationship, cleft lip or palate (or both), or other…
1 finding from 1 review
Molar expansion · Children and adults with a posterior crossbite, without a Class III skeletal relationship, cleft lip or palate (or both), or other…
1 finding from 1 review
Crossbite correction · Children and adults with a posterior crossbite, without a Class III skeletal relationship, cleft lip or palate (or both), or other…
1 finding from 1 review
Open TMJ surgery (arthroplasty / total joint replacement)
Outcome not reported · Adults (>18 years) with temporomandibular joint osteoarthritis (TMJ OA) diagnosed by RDC/TMD or compatible criteria
The review found no eligible studies for this question.
1 finding from 1 review
General ventilation (e.g. natural ventilation, exhaust fans, opening windows) vs No general ventilation / standard operatory
Outcome not reported · Dental healthcare providers (dentist, dental surgery assistant, dental hygienist, dental technologist, dental laboratory staff, dental…
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
0 studies
No studies found
Relief of burning/discomfort (symptom relief; pain intensity) · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms
1 finding from 1 review
Interventions for treating burning mouth syndrome 2016 · Cochrane All outcomesshort-term (up to 3 months)
SoF5 Dietary supplements vs placebo. Symptom relief short-term: insufficient or contradictory evidence regarding benefit of any evaluated dietary supplement; 628 participants (12 RCTs); very low. Subgroups: ALA without…
12 studies · 628 participants
Very low
Retention success rate · Children with primary molars requiring proximal (Class II) restorations
For the Rubber dam isolation: Yes subgroup, the 24-month retention success rate was 0.931 (95% CI 0.834-0.973; ungraded).
28 findings from 1 review
Proportion 0.931 [0.834, 0.973]
10 studies
GRADE not reported
Proportion 0.867 [0.779, 0.924]
24 studies
GRADE not reported
Proportion 0.805 [0.674, 0.892]
16 studies
GRADE not reported
Show 25 more findings
Proportion 0.934 [0.859, 0.971]
11 studies
GRADE not reported
Proportion 0.824 [0.672, 0.914]
8 studies
GRADE not reported
Proportion 0.554 [0.168, 0.885]
2 studies
GRADE not reported
Proportion 0.649 [0.488, 0.783]
8 studies
GRADE not reported
Proportion 0.950 [0.639, 0.995]
1 study
GRADE not reported
Proportion 0.879 [0.803, 0.928]
27 studies
GRADE not reported
Proportion 0.935 [0.726, 0.987]
3 studies
GRADE not reported
Proportion 0.904 [0.474, 0.989]
3 studies
GRADE not reported
Proportion 0.949 [0.868, 0.981]
7 studies
GRADE not reported
Proportion 0.826 [0.605, 0.937]
10 studies
GRADE not reported
Proportion 0.839 [0.764, 0.893]
34 (27 observed + 7 imputed) studies
GRADE not reported
Proportion 0.936 [0.895, 0.961]
19 studies
GRADE not reported
Proportion 0.854 [0.718, 0.931]
15 studies
GRADE not reported
Proportion 0.897 [0.792, 0.952]
12 studies
GRADE not reported
Proportion 0.956 [0.865, 0.986]
5 studies
GRADE not reported
Proportion 0.973 [0.695, 0.998]
2 studies
GRADE not reported
Proportion 0.851 [0.716, 0.929]
15 studies
GRADE not reported
Proportion 0.895 [0.828, 0.938]
25 studies
GRADE not reported
Proportion 0.899 [0.768, 0.961]
9 studies
GRADE not reported
Proportion 0.847 [0.726, 0.920]
14 studies
GRADE not reported
Proportion 0.854 [0.609, 0.956]
9 studies
GRADE not reported
Proportion 0.671 [0.447, 0.838]
6 studies
GRADE not reported
Proportion 0.892 [0.614, 0.977]
3 studies
GRADE not reported
Proportion 0.807 [0.482, 0.949]
5 studies
GRADE not reported
Proportion 0.909 [0.785, 0.965]
12 studies
GRADE not reported
Marginal integrity success rate · Children with primary molars requiring proximal (Class II) restorations
After trim-and-fill adjustment the marginal integrity success rate was 0.881 (95% CI 0.832-0.916; ungraded), a negligible change.
2 findings from 1 review
Proportion 0.881 [0.832, 0.916]
32 (27 observed + 5 imputed) studies
GRADE not reported
Proportion 0.898 [0.852, 0.931]
27 studies
GRADE not reported