Question · asked by 1 review
Antioxidants (lycopene, curcumin, Oxitard) vs Placebo or no active treatment: Burning sensation (VAS 0-100)
- Population
- People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
- Intervention
- Antioxidants (lycopene, curcumin, Oxitard)
- Comparison
- Placebo or no active treatment
- Outcome
- Burning sensation (VAS 0-100)
Antioxidants (lycopene, curcumin, Oxitard) probably leads to lower burning sensation (VAS 0-100) compared with placebo or no active treatment (moderate certainty).
What each review found
Include earlier review versionsNo studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 3 · 100%High 0 · 0%
| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Antioxidants (lycopene, curcumin, Oxitard) vs Placebo or no active treatment Burning sensation (VAS 0-100) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF) · 3 to 6 months Antioxidants (lycopene, curcumin, Oxitard) probably leads to lower burning sensation (VAS 0-100) compared with placebo or no active treatment (moderate certainty). Interventions for managing oral submucous fibrosis (2024) · Cochrane All outcomes | MD -70.82 [-94.39, -47.25] | 2 studies · 500 participants | Moderate |
Antioxidants (lycopene, curcumin, Oxitard) vs Placebo or no active treatment Burning sensation (VAS 0-100) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF) · Less than 3 months Antioxidants (lycopene, curcumin, Oxitard) probably leads to lower burning sensation (VAS 0-100) compared with placebo or no active treatment (moderate certainty). Interventions for managing oral submucous fibrosis (2024) · Cochrane All outcomes | MD -30.92 [-31.57, -30.27] | 1 study · 400 participants | Moderate |
Antioxidants (lycopene, curcumin, Oxitard) vs Placebo or no active treatment Burning sensation (VAS 0-100) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF) · More than 6 months Antioxidants (lycopene, curcumin, Oxitard) probably leads to lower burning sensation (VAS 0-100) compared with placebo or no active treatment (moderate certainty). Interventions for managing oral submucous fibrosis (2024) · Cochrane All outcomes | MD -27.60 [-36.21, -18.99] | 1 study · 90 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Interventions for managing oral submucous fibrosis 2024 · Cochrane All outcomes | 2022-09 | Not listed | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.