Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,149 questions · 1,211 findings · 179 reviews

No studies found 175 · 14.5%GRADE not reported 86 · 7.1%Very low 286 · 23.6%Low 341 · 28.2%Moderate 254 · 21%High 69 · 5.7%

Are disease‐modifying drugs for a first attack suggestive of multiple sclerosis (MS) effective and safe vs placebo?

Disability worsening

It is very uncertain whether are disease‐modifying drugs for a first attack suggestive of… changes disability‐worsening Proportion of participants with… compared with placebo? (very low certainty).

1 finding from 1 review

Are disease‐modifying drugs for a first attack suggestive of multiple sclerosis (MS) effective and safe vs placebo?

Relapse

It is very uncertain whether are disease‐modifying drugs for a first attack suggestive of… changes relapse Proportion of participants with relapse during 24 months of… compared with placebo? (very low certainty).

1 finding from 1 review

Are disease‐modifying drugs for a first attack suggestive of multiple sclerosis (MS) effective and safe vs placebo?

Adverse effects: at least one serious adverse event

Are disease‐modifying drugs for a first attack suggestive of… showed no clear difference in occurrence of at least one serious adverse event Proportion of… compared with placebo? (low certainty).

1 finding from 1 review

Are disease‐modifying drugs for a first attack suggestive of multiple sclerosis (MS) effective and safe vs placebo?

Discontinuation of medication due to adverse events

It is very uncertain whether are disease‐modifying drugs for a first attack suggestive of… changes withdrawls or drug discontinuation due to adverse events during 24… compared with placebo? (very low certainty).

1 finding from 1 review

(ITS) Multiple safe devices vs regular devices

Needle stick injuries · preventing percutaneous exposure injuries caused by needles in healthcare personnel

It is very uncertain whether (CBA) Multiple safe devices changes needle stick injuries compared with regular devices (very low certainty).

1 finding from 1 review

Multiple doses of deworming drugs vs placebo

Death (between ages 1 and 6 years) · public health programmes to regularly treat all children aged 16 years or less

Multiple doses of deworming drugs showed no clear difference in mortality (between ages 1 and 6 years) compared with placebo (low certainty).

1 finding from 1 review