Findings

What do systematic reviews say?

65 questions · 65 findings · 32 reviews · Airways

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No studies found 4 · 6.2%GRADE not reported 1 · 1.5%Very low 8 · 12.3%Low 18 · 27.7%Moderate 26 · 40%High 8 · 12.3%

Antibiotics vs placebo

HRQoL: total score · Adults (aged 40 or over) with COPD presenting with 1 or more exacerbations in the previous year. The 2 larger studies (Albert 2011; Sethi…

1 finding from 1 review

Prophylactic antibiotic therapy for chronic obstructive pulmonary disease (COPD) 2018 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 2237 participants
High

Antibiotics vs placebo

All‐cause mortality WMD of · Adults (aged 40 or over) with COPD presenting with 1 or more exacerbations in the previous year. The 2 larger studies (Albert 2011; Sethi…

Antibiotics showed no clear difference in all‐cause mortality WMD of compared with placebo (moderate certainty).

1 finding from 1 review

Prophylactic antibiotic therapy for chronic obstructive pulmonary disease (COPD) 2018 · Cochrane Headline outcomes only
OR 0.87 [0.66, 1.15]
6 studies · 3309 participants
Moderate

Antibiotics vs placebo

Serious adverse events WMD of · Adults (aged 40 or over) with COPD presenting with 1 or more exacerbations in the previous year. The 2 larger studies (Albert 2011; Sethi…

Antibiotics showed no clear difference in serious adverse events WMD of compared with placebo (moderate certainty).

1 finding from 1 review

Prophylactic antibiotic therapy for chronic obstructive pulmonary disease (COPD) 2018 · Cochrane Headline outcomes only
OR 0.88 [0.74, 1.05]
9 studies · 2978 participants
Moderate

Antibiotics vs placebo

Any adverse event WMD of · Adults (aged 40 or over) with COPD presenting with 1 or more exacerbations in the previous year. The 2 larger studies (Albert 2011; Sethi…

Antibiotics showed no clear difference in any adverse event WMD of compared with placebo (moderate certainty).

1 finding from 1 review

Prophylactic antibiotic therapy for chronic obstructive pulmonary disease (COPD) 2018 · Cochrane Headline outcomes only
OR 1.07 [0.69, 1.67]
4 studies · 512 participants
Moderate

Antibiotics vs placebo

FEV1 · Adults (aged 40 or over) with COPD presenting with 1 or more exacerbations in the previous year. The 2 larger studies (Albert 2011; Sethi…

1 finding from 1 review

Prophylactic antibiotic therapy for chronic obstructive pulmonary disease (COPD) 2018 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 658 participants
Moderate