Findings

What do systematic reviews say?

63 questions · 68 findings · 13 reviews

No studies found 5 · 7.4%GRADE not reported 0 · 0%Very low 10 · 14.7%Low 33 · 48.5%Moderate 13 · 19.1%High 7 · 10.3%

Morphine positive urine or hair analysis objective · patients with opioid dependence

The intervention leads to lower morphine positive urine or hair analysis objective (high certainty).

1 finding from 1 review

Methadone maintenance therapy versus no opioid replacement therapy for opioid dependence 2009 · Cochrane Headline outcomes only
RR 0.66 [0.56, 0.78]
6 studies · 1129 participants
High

Criminal activity objective · patients with opioid dependence

The intervention showed no clear difference in criminal activity objective (moderate certainty).

1 finding from 1 review

Methadone maintenance therapy versus no opioid replacement therapy for opioid dependence 2009 · Cochrane Headline outcomes only
RR 0.39 [0.12, 1.25]
3 studies · 363 participants
Moderate

Mortality objective · patients with opioid dependence

The intervention showed no clear difference in mortality objective (moderate certainty).

1 finding from 1 review

Methadone maintenance therapy versus no opioid replacement therapy for opioid dependence 2009 · Cochrane Headline outcomes only
RR 0.48 [0.1, 2.39]
4 studies · 576 participants
Moderate